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首页> 外文期刊>Circulation journal >High-normal thyroid function and risk of recurrence of atrial fibrillation after catheter ablation.
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High-normal thyroid function and risk of recurrence of atrial fibrillation after catheter ablation.

机译：甲状腺功能正常，导管消融后出现房颤复发的风险。

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BACKGROUND: It has been shown that the concentration of serum free thyroxine (FT(4)) is independently associated with atrial fibrillation (AF), even in euthyroid persons. This study investigated the effect of a high-normal level of FT(4) on recurrence after catheter ablation of AF. METHODS AND RESULTS: The 244 consecutive patients with paroxysmal AF and who underwent circumferential pulmonary vein isolation (PVI) were prospectively enrolled. Exclusion criteria included prior or current thyroid dysfunction on admission, amiodarone medication for 3 months before admission. After a mean follow-up of 416+/-204 (91-856) days, the recurrence rates were 14.8%, 23.0%, 33.3%, 38.7% from the lowest FT(4) quartile to the highest FT(4) quartile, respectively (P=0.016). After adjustment for age, sex, left atrial diameter, and PVI, there was an increased risk of recurrence in the subjects with the highest FT(4) quartile compared with those with the lowest quartile (hazard ratio 3.31, 95% confidence interval 1.45-7.54, P=0.004). As a continuous variable, FT(4) was also an independent predictor of recurrence (hazard ratio 1.10, 95% confidence interval 1.02-1.18, P=0.016). CONCLUSIONS: Patients with high-normal thyroid function were at an increased risk of AF recurrence after catheter ablation.
机译：背景：研究表明，即使在甲状腺功能正常的人中，血清游离甲状腺素（FT（4））的浓度也与房颤（AF）独立相关。这项研究调查了高水平的FT（4）对房颤导管消融后复发的影响。方法和结果：前瞻性纳入了244例连续发作的阵发性房颤并进行了圆周肺静脉隔离术（PVI）的患者。排除标准包括入院前或目前的甲状腺功能障碍，入院前3个月使用胺碘酮治疗。平均随访416 +/- 204（91-856）天，从最低FT（4）四分位数到最高FT（4）四分位数的复发率分别为14.8％，23.0％，33.3％，38.7％。 ，分别为（P = 0.016）。在对年龄，性别，左心房直径和PVI进行调整后，与四分位数最低的患者相比，FT（4）四分位数最高的患者发生复发的风险增加（危险比3.31，95％置信区间1.45- 7.54，P = 0.004）。作为连续变量，FT（4）还是复发的独立预测因子（危险比1.10，95％置信区间1.02-1.18，P = 0.016）。结论：甲状腺功能正常的患者在导管消融后发生房颤复发的风险增加。

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