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首页> 外文期刊>Circulation journal >Epicardial adipose tissue radiodensity is independently related to coronary atherosclerosis. A multidetector computed tomography study.
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Epicardial adipose tissue radiodensity is independently related to coronary atherosclerosis. A multidetector computed tomography study.

机译：心外膜脂肪组织的放射密度与冠状动脉粥样硬化独立相关。多探测器计算机断层扫描研究。

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BACKGROUND: Preliminary research indicates that epicardial adipose tissue (EAT) may display both anti- and proatherosclerotic properties. Because the varying radiodensities of selected human tissues assessed by multidetector computed tomography (MDCT) has been shown to reflect differences in biological characteristics, the present study investigated the hypothesis that the proatherosclerotic properties of EAT may be linked to its radiodensity. METHODS AND RESULTS: The study included 164 consecutive patients (82 females, mean age 58.8+/-11.1 years) with suspected coronary artery disease (CAD) undergoing MDCT coronary angiography. Coronary atherosclerosis was defined as: (1) CAD (ie, presence of at least 1 coronary stenosis >/=50%) and (2) coronary artery calcium (CAC) determined by Agatston score. EAT radiodensity was assessed by MDCT and averaged 81.00+/-4.64 HU (Hounsfield unit (HU) scale). Mean CAC score was 96.0+/-220.0. Patients with CAD (n=36) showed higher EAT radiodensity than patients without CAD (78.99+/-4.12 vs. -81.57+/-4.64 HU, P<0.01). In the multivariable model, only EAT radiodensity and age were independently associated with CAD (odds ratio (OR) 1.15, 95%confidence interval (CI) 1.04-1.28; OR 1.08, 95%CI 1.04-1.12; respectively). EAT radiodensity also correlated with CAC score (r=0.23, P<0.01). EAT radiodensity (P<0.001), age (P<0.001), sex (P=0.03), and past smoking (P<0.01) were independent correlates of CAC in the multivariable linear regression model. CONCLUSIONS: Increased EAT radiodensity is independently associated with coronary atherosclerosis, which may reflect the unfavorable, proatherosclerotic metabolic properties of more radiodense epicardial fat.
机译：背景：初步研究表明，心外膜脂肪组织（EAT）可能同时具有抗动脉粥样硬化特性和前动脉粥样硬化特性。由于已显示通过多探测器计算机断层扫描（MDCT）评估的选定人体组织的不同放射线密度反映了生物学特征的差异，因此本研究调查了EAT的动脉粥样硬化特性可能与其放射线密度相关的假设。方法和结果：该研究纳入了164例接受MDCT冠状动脉造影的连续疑似冠心病（CAD）的患者（82例女性，平均年龄58.8 +/- 11.1岁）。冠状动脉粥样硬化定义为：（1）CAD（即，存在至少1个冠状动脉狭窄> / = 50％）和（2）通过Agatston评分确定的冠状动脉钙（CAC）。 EAT的放射密度通过MDCT评估，平均为81.00 +/- 4.64 HU（Hounsfield单位（HU）量表）。平均CAC分数为96.0 +/- 220.0。有CAD的患者（n = 36）的EAT放射密度高于无CAD的患者（78.99 +/- 4.12 vs -81.57 +/- 4.64 HU，P <0.01）。在多变量模型中，只有EAT的辐射密度和年龄与CAD独立相关（优势比（OR）1.15，95％置信区间（CI）1.04-1.28; OR 1.08，95％CI 1.04-1.12）。 EAT的放射密度也与CAC评分相关（r = 0.23，P <0.01）。在多变量线性回归模型中，EAT放射密度（P <0.001），年龄（P <0.001），性别（P = 0.03）和既往吸烟（P <0.01）是CAC的独立相关因素。结论：增加的EAT放射密度与冠状动脉粥样硬化独立相关，这可能反映了较高的放射致密性心外膜脂肪的不利的，粥样硬化的代谢特性。

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