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首页> 外文期刊>Journal of abnormal psychology >Progression along the bipolar spectrum: a longitudinal study of predictors of conversion from bipolar spectrum conditions to bipolar I and II disorders.
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Progression along the bipolar spectrum: a longitudinal study of predictors of conversion from bipolar spectrum conditions to bipolar I and II disorders.

机译：沿双极谱的进展：纵向研究预测从双极谱状况到双相I和II型疾病的转换。

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Little longitudinal research has examined progression to more severe bipolar disorders in individuals with "soft" bipolar spectrum conditions. We examine rates and predictors of progression to bipolar I and II diagnoses in a nonpatient sample of college-age participants (n = 201) with high General Behavior Inventory scores and childhood or adolescent onset of "soft" bipolar spectrum disorders followed longitudinally for 4.5 years from the Longitudinal Investigation of Bipolar Spectrum (LIBS) project. Of 57 individuals with initial cyclothymia or bipolar disorder not otherwise specified (BiNOS) diagnoses, 42.1% progressed to a bipolar II diagnosis and 10.5% progressed to a bipolar I diagnosis. Of 144 individuals with initial bipolar II diagnoses, 17.4% progressed to a bipolar I diagnosis. Consistent with hypotheses derived from the clinical literature and the Behavioral Approach System (BAS) model of bipolar disorder, and controlling for relevant variables (length of follow-up, initial depressive and hypomanic symptoms, treatment-seeking, and family history), high BAS sensitivity (especially BAS Fun Seeking) predicted a greater likelihood of progression to bipolar II disorder, whereas early age of onset and high impulsivity predicted a greater likelihood of progression to bipolar I (high BAS sensitivity and Fun-Seeking also predicted progression to bipolar I when family history was not controlled). The interaction of high BAS and high Behavioral Inhibition System (BIS) sensitivities also predicted greater likelihood of progression to bipolar I. We discuss implications of the findings for the bipolar spectrum concept, the BAS model of bipolar disorder, and early intervention efforts.
机译：很少有纵向研究检查了患有“软性”双极性频谱状况的个体向更严重的双相情感障碍的进展。我们在非患者样本中，通过一般行为量表得分高且儿童或青少年期出现“软性”双相频谱障碍的儿童或青少年发作，纵向研究了4.5年，对非患者样本（n = 201）进行了研究，并评估了进展为双相I和II诊断的速率和预测指标。来自双极谱纵向调查（LIBS）项目。在57例初发性心律不齐或双相情感障碍（未另作说明）的患者中，有42.1％进行了双相II型诊断，10.5％进行了双相I型诊断。在144位最初患有双相II型诊断的个体中，有17.4％的患者进展为双相I型诊断。与临床文献和双相情感障碍行为方法系统（BAS）模型得出的假设一致，并控制相关变量（随访时间，初始抑郁和轻躁狂症状，寻求治疗和家族史），高BAS敏感性（尤其是BAS寻求乐趣）预示着发展为双相II型障碍的可能性更大，而发病年龄早和高冲动性预示着发展为双相I的可能性更大（BAS敏感性高和寻求乐趣也预示着发展为双相I障碍。家族史不受控制）。高BAS和高行为抑制系统（BIS）敏感性之间的相互作用也预示了发展为双相I的可能性更高。我们讨论了该发现对双相谱概念，双相障碍BAS模型以及早期干预工作的意义。

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