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首页> 外文期刊>Circulation journal >Assessment of the histological characteristics of coronary arterial plaque with severe calcification.
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Assessment of the histological characteristics of coronary arterial plaque with severe calcification.

机译：严重钙化评估冠状动脉斑块的组织学特征。

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BACKGROUND: Several studies have shown that rotational atherectomy (RA) is associated with higher rates of the slow-flow phenomenon and that ablated particles may be the possible cause. Intravascular ultrasound (IVUS) has an intrinsic limitation in assessing plaque morphology behind the calcification because of acoustic shadowing. Therefore, the purpose of this study was to investigate plaque characteristics behind severe calcification by histological examination. METHODS AND RESULTS: One hundred eight coronary arterial segments from 40 human cadavers (24 males, 16 females, mean age 74+/-7 years) were examined. Serial images of IVUS were obtained and 18 severe calcified lesions were collected. Experienced observers quantitatively analyzed the lesions by computerized planimetry for fibrous, fibrofatty, calcification, and necrotic tissue area. Histologically, 15 of 18 severely calcified lesions (83%) had an extensive necrotic tissue containing large numbers of cholesterol crystals and microcalcifications; 16 of same 18 severely calcified lesions (89%) had fibrofatty tissue as well as calcification. The necrotic tissue occupied 14+/-13% and fibrofatty tissue occupied 13+/-11% of severely calcified lesions. CONCLUSION: Necrotic core and fibrofatty tissue components "hidden" behind calcification might cause emboli-induced thrombus formation and distal flow disturbance during RA.
机译：背景：几项研究表明，旋磨术（RA）与慢血流现象的发生率较高相关，而烧蚀的颗粒可能是造成这种情况的原因。血管内超声（IVUS）在评估钙化后的斑块形态方面存在固有的局限性，这是因为声学阴影。因此，本研究的目的是通过组织学检查来研究严重钙化背后的斑块特征。方法和结果：检查了来自40具尸体（男性24例，女性16例，平均年龄74 +/- 7岁）的108个冠状动脉节段。获得了IVUS的系列图像，并收集了18个严重的钙化病变。经验丰富的观察者通过计算机化的平面法定量分析了病变的纤维，纤维脂肪，钙化和坏死组织区域。从组织学上看，18个严重钙化病变中有15个（占83％）具有广泛的坏死组织，其中含有大量的胆固醇晶体和微钙化。在18个严重钙化病变中，有16个（89％）具有脂肪组织和钙化。坏死组织占严重钙化病变的14 +/- 13％，而纤维脂肪组织占13 +/- 11％。结论：钙化后“隐藏”的坏死核心和纤维脂肪组织成分可能导致栓塞诱导的血栓形成和RA远端血流紊乱。

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