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Pathogenesis of fibromyalgia - a review.

机译:纤维肌痛的发病机理-综述。

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Fibromyalgia, a syndrome characterized by widespread pain and diffuse tenderness, is considered a multifactorial disorder. Central nervous system sensitization is a major pathophysiological aspect of fibromyalgia, while various external stimuli such as infection, trauma and stress may contribute to development of the syndrome. In addition, current evidence points towards the existence of a genetic basis for fibromyalgia and information has been accumulated regarding the role of a number of candidate genes in fibromyalgia pathogenesis. In the present review, we have summarized the clinical manifestations of fibromyalgia, as well as the necessary laboratory workup; subsequently we have attempted to cover various aspects of pathogenesis with special emphasis on the genetic aspects currently uncovered.
机译:纤维肌痛是一种以广泛的疼痛和弥漫性压痛为特征的综合症,被认为是一种多因素疾病。中枢神经系统敏化是纤维肌痛的主要病理生理方面,而各种外部刺激(例如感染,创伤和压力)可能会导致该综合征的发展。另外,目前的证据指出了纤维肌痛的遗传基础的存在,并且已经积累了关于许多候选基因在纤维肌痛发病机理中的作用的信息。在本综述中,我们总结了纤维肌痛的临床表现以及必要的实验室检查。随后,我们尝试涵盖发病机理的各个方面,特别强调当前发现的遗传方面。

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