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首页> 外文期刊>Joint, bone, spine : >Antiepileptic drugs to treat pain in rheumatic conditions. Recommendations based on evidence-based review of the literature and expert opinion.
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Antiepileptic drugs to treat pain in rheumatic conditions. Recommendations based on evidence-based review of the literature and expert opinion.

机译：抗风湿药可治疗风湿病中的疼痛。基于对文献和专家意见进行循证审查的建议。

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OBJECTIVES: Neuropathic pain is commonly encountered in rheumatology practice, often associated with nociceptive mechanisms. It is caused by nervous system lesions, and the usual treatments with analgesics and anti-inflammatory drugs are mostly ineffective. Antiepileptic drugs (AED) have proved effective in relieving neuropathic pain. AED are recently used by rheumatologists since the role of neuropathic pain in rheumatological conditions has only recently been documented. Nevertheless, the tendency seems to be reversed when these drugs are used inappropriately. The CEDR (Cercle d'Etude de la Douleur en Rhumatologie), a specific interest group of the French Society of Rheumatology that focuses on pain in rheumatology, undertook to develop recommendations for the use of AED in Rheumatology. METHODS: A list of questions concerning the prescription of AED in painful rheumatic conditions was validated by a working group of 7 experts from the CEDR. The list of questions was used to draw up the recommendations. A literature review was performed using electronic databases (Medline, Embase and Cochrane library between 1980 and 2007) without limitations on the type of publication: case reports, clinical trials, literature review and guidelines about therapeutic management of neuropathic pain. Selected studies were scored for quality. Based on the literature and clinical experience, recommendations were developed using the Delphi method. RESULTS: We identified 29 studies concerning the use of AED in painful rheumatic conditions and 16 studies were considered valid and scored for quality. These few studies, the guidelines published for neuropathic pain treatment and the clinical experience of each expert, were used to develop 11 recommendations for the use of AED in painful rheumatic conditions. CONCLUSION: These recommendations can be used as guidelines to help prescribers to use AED for the management of pain in rheumatic conditions until further scientific evidence becomes available.
机译：目的：风湿病实践中通常会遇到神经性疼痛，并且通常与伤害感受机制有关。它是由神经系统病变引起的，通常使用镇痛药和消炎药的治疗大多无效。已证明抗癫痫药（AED）可有效缓解神经性疼痛。风湿病学家最近使用了AED，因为神经病性疼痛在风湿病中的作用只是最近才有文献报道。然而，当这些药物使用不当时，这种趋势似乎可以逆转。法国风湿病学会的一个特殊兴趣团体CEDR（风湿病学中心）致力于为风湿病学中使用AED提出建议。方法：CEDR的7名专家组成的工作组验证了有关在风湿性疼痛中AED处方的问题清单。问题列表用于起草建议。使用电子数据库（1980年至2007年间，Medline，Embase和Cochrane库）进行了文献复习，但没有对出版物类型的限制：病例报告，临床试验，文献复习和有关神经性疼痛的治疗方法的指南。对选定的研究进行质量评分。基于文献和临床经验，使用德尔菲方法制定了建议。结果：我们确定了29项关于在疼痛风湿病中使用AED的研究，其中16项研究被认为是有效的，并对其质量进行了评分。这几项研究，有关神经性疼痛治疗的指南以及每位专家的临床经验均被用于针对疼痛性风湿病制定11条AED的建议。结论：这些建议可作为指导原则，以帮助开处方者在风湿条件下使用AED治疗疼痛，直至获得进一步的科学依据。

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