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The roles of interferons in osteoclasts and osteoclastogenesis

机译：干扰素在破骨细胞和破骨细胞形成中的作用

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摘要

Interferons (IFNs) play essential roles in regulating osteoclast differentiation and bone resorption. Over the last decade, we have seen tremendous developments in our understanding of the mechanisms by which interferons regulate osteoclastogenesis. Of the type I interferons, IFN-beta inhibits osteoclastogenesis via autoregulatory or exogenous regulatory mechanisms, while IFN-alpha was recently shown to participate in regulating osteoclast formation. And the only member of type II interferons, IFN-gamma, has biphasic effects on osteoclastogenesis. Type III interferons have also been shown to be involved in osteoclast bone resorption, although no direct regulatory mechanism has been demonstrated. In this review, we provide an update account of the current knowledge on these recently revealed novel roles of interferons in the regulation of a variety of signaling pathways in osteoclast differentiation and function. The potential clinical applications are also discussed. (C) 2015 Societe francaise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.
机译：干扰素（IFN）在调节破骨细胞分化和骨吸收中起重要作用。在过去的十年中，我们对干扰素调节破骨细胞发生机理的理解有了长足的发展。在I型干扰素中，IFN-β通过自身调节或外源调节机制抑制破骨细胞生成，而IFN-α最近被证明参与调节破骨细胞形成。 II型干扰素的唯一成员IFN-γ对破骨细胞的生成具有双相作用。尽管还没有直接的调节机制，但III型干扰素也被证明参与破骨细胞的骨吸收。在这篇综述中，我们提供了有关这些最近揭示的干扰素在破骨细胞分化和功能中各种信号通路调控中新作用的最新知识的最新信息。还讨论了潜在的临床应用。 （C）2015法国社会科学学会。由Elsevier Masson SAS发布。版权所有。

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