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首页> 外文期刊>Circulation journal >Smoking promotes subclinical atherosclerosis in apparently healthy men: 2-year ultrasonographic follow-up
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Smoking promotes subclinical atherosclerosis in apparently healthy men: 2-year ultrasonographic follow-up

机译：吸烟可促进显然健康的男性亚临床动脉粥样硬化：2年超声检查

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Background: Smoking is a major risk factor for cardiovascular disease. Also, inflammatory activation and metabolic disorder are the mediators of smoking-induced atherosclerotic progression. The aim of the present study was to investigate whether current smoking and smoking cessation alter inflammatory or metabolic status and affect subclinical atherosclerosis in apparently healthy men. Methods and Results: Classical risk factors and smoking habit were evaluated in 354 men who completed health examinations annually without any current medications. Carotid intima-media thickness (IMT) was followed for 27.1 ±4.5 months. At baseline, both maximum and mean IMT significantly changed during 2-year follow-up. They tended to increase along with progression of smoking habit, with significantly greater maximum IMT in current smokers compared with never smokers. Both maximum and mean IMT significantly changed during 2-year follow-up, and tended to increase with progression of smoking habit, with maximum IMT being greatest for current smokers. Past smokers tended to have greater IMT increase than never smokers. Among smoking habit and some atherosclerotic risk markers that showed significant correlation with maximum IMT increase, stepwise regression showed that smoking habit and serum low-density lipoprotein-cholesterol (LDL-C) level were the only independent predictors. Conclusions: Significant 2-year progression of subclinical atherosclerosis was associated with continuous smoking and LDL-C. This was only partly moderated in past smokers despite complete reversal of inflammatory activation, suggesting another crucial factor for inhibiting accelerated progression of subclinical atherosclerosis in men.
机译：背景：吸烟是心血管疾病的主要危险因素。同样，炎症激活和代谢紊乱是吸烟引起的动脉粥样硬化进展的介质。本研究的目的是调查目前吸烟和戒烟是否会改变看似健康的男性的炎症或代谢状态并影响亚临床动脉粥样硬化。方法和结果：对每年完成354例健康检查且没有任何药物治疗的男性中的经典危险因素和吸烟习惯进行了评估。随访颈动脉内膜中层厚度（IMT）27.1±4.5个月。在基线时，在2年的随访期间，最大和平均IMT均发生了显着变化。他们倾向于随着吸烟习惯的发展而增加，目前吸烟者的最大IMT明显高于从未吸烟者。在为期两年的随访中，最大和平均IMT均发生了显着变化，并且随着吸烟习惯的发展而增加，最大IMT对当前吸烟者最大。过去的吸烟者往往比从未吸烟者有更大的IMT增加。在吸烟习惯和某些动脉粥样硬化危险标志物与最大IMT增加之间存在显着相关性，逐步回归显示吸烟习惯和血清低密度脂蛋白胆固醇（LDL-C）水平是唯一的独立预测因子。结论：亚临床动脉粥样硬化的显着2年进展与持续吸烟和LDL-C有关。尽管炎症激活完全逆转，但在过去的吸烟者中仅部分缓解了这一现象，这表明抑制男性亚临床动脉粥样硬化加速发展的另一个关键因素。

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