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首页> 外文期刊>Circulation journal >Reverse redistribution phenomenon on rest (99m)Tc-tetrofosmin myocardial single photon emission computed tomography involves impaired left ventricular contraction in patients with acute myocardial infarction.
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Reverse redistribution phenomenon on rest (99m)Tc-tetrofosmin myocardial single photon emission computed tomography involves impaired left ventricular contraction in patients with acute myocardial infarction.

机译：静息（99m）Tc-四磷酸磷铵心肌单光子发射计算机断层扫描的反向再分布现象涉及急性心肌梗死患者的左心室收缩受损。

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摘要

The purpose of this study was to investigate the clinical significance of the reverse redistribution (RR) phenomenon on technetium-99m ((99m)Tc)-tetrofosmin myocardial single photon emission computed tomography (SPECT) performed at rest. Twenty-five patients underwent myocardial SPECT 3 weeks after the onset of acute myocardial infarction. Myocardial images were acquired at 40 min (early) and 4 h (delayed) after the injection of 740 MBq of (99m)Tc-tetrofosmin. The regional myocardial uptake of the tracer in 26 segments of the left ventricular (LV) wall was visually scored from 0 (no activity) to 3 (normal activity), and then the RR was defined as a decrease of more than 1 point in the activity score on the delayed image compared with that on the early image. Regions with an activity score of 3 on both the early and delayed images were defined as normal, and those with a score of 0 or 1 on the early image were considered to have a fixed defect. The regional myocardial (99m)Tc-tetrofosmin uptake and washout rate were also quantitatively assessed in each region. In addition, exercise stress electrocardiograph-gated SPECT with (99m)Tc-tetrofosmin was performed within 1 week of the rest study, and the percent count increase (%CI) during myocardial contraction in each corresponding region was studied. RR was observed in 18 of the 25 patients. The regional washout rate of (99m)Tc-tetrofosmin was significantly higher in the RR regions (45.0+/-3.8%) than in either the normal regions (36.4+/-4.1%, p<0.001) or in those with a fixed defect (39.7+/-3.9%, p<0.001). The %CI in the RR regions (10.4+/-10.4%) was significantly less than that in the normal regions (23.5+/-10.1%, p<0.001); however, no significant difference was found between the RR regions and those with a fixed defect (8.0+/-7.2%). In patients with acute myocardial infarction, the regions showing the RR phenomenon on (99m)Tc-tetrofosmin SPECT have severely impaired LV wall contraction after exercise.
机译：这项研究的目的是调查在休息时执行tech 99m（（99m）Tc）-替福福明心肌单光子发射计算机断层扫描（SPECT）的反向再分布（RR）现象的临床意义。急性心肌梗塞发作后3周，对25例患者进行了心肌SPECT检查。注射740 MBq的（99m）Tc-四氟磷酰胺后40分钟（早期）和4小时（延迟）获取心肌图像。在视觉上将左心室（LV）壁的26个部分中示踪剂的区域性心肌摄取从0（无活动）评分为3（正常活动），然后将RR定义为将RR降低超过1点与早期图像相比，延迟图像上的活动评分。在早期图像和延迟图像上的活动评分均为3的区域被定义为正常区域，在早期图像上的活动评分为0或1的区域被认为具有固定的缺陷。还定量评估了每个区域的局部心肌（99m）Tc-四氟膦吸收和清除率。此外，在其余研究的1周内进行了运动应力心电图门控的SPECT联合（99m）Tc-四磷灵的研究，并研究了每个相应区域心肌收缩过程中百分比计数增加（％CI）。 25例患者中有18例观察到RR。 （99m）Tc-tetrofosmin的区域冲洗率在RR区（45.0 +/- 3.8％）显着高于正常区（36.4 +/- 4.1％，p <0.001）或固定区缺陷（39.7 +/- 3.9％，p <0.001）。 RR区域的％CI（10.4 +/- 10.4％）显着低于正常区域的％CI（23.5 +/- 10.1％，p <0.001）;然而，在RR区域与具有固定缺陷的区域之间没有发现显着差异（8.0 +/- 7.2％）。在患有急性心肌梗塞的患者中，运动后（99m）Tc-tetrofosmin SPECT上显示RR现象的区域严重损害了左室壁收缩。

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