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首页> 外文期刊>Circulation journal >Sustained attenuation of neointimal coverage over the stent following brachytherapy for in-stent restenosis: angioscopic findings.
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Sustained attenuation of neointimal coverage over the stent following brachytherapy for in-stent restenosis: angioscopic findings.

机译：支架内再狭窄近距离放疗后新内膜覆盖物的持续衰减：血管镜检查结果。

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摘要

BACKGROUND: The nature of the vessel lumen following vascular brachytherapy (VBT) has not been extensively explored in the clinical setting. METHODS AND RESULTS: By using angioscopy, 33 stents treated with percutaneous balloon angioplasty with or without VBT for in-stent restenosis after 8.9 +/- 2.1 months of the treatment were followed (VBT 14 lesions; control and the presence of red or white thrombi were factors that were assessed. The majority of the stents (74%) were fully covered with non-transparent neointima in the control group. In contrast, stent struts were clearly seen in 57% lesions with VBT. The absence of neointima with glittering stent struts were only seen in 29% of lesions in VBT (p = 0.03). Incomplete stent attachment was not detected in the controls, whereas 14% were in VBT (p = 0.17). Red thrombi were observed in 14% with VBT and in 16% in controls, which showed that there was a similar incidence regardless of the treatment. Neither exposure of stent struts (p = 0.5) nor incomplete stent attachment (p = 1.0) was related to thrombi. CONCLUSIONS: The exposure of stent struts and incomplete stent attachment were occasionally observed by angioscopy even 9 months after VBT for the treatment of in-stent restenosis.
机译：背景：血管近距离放射治疗（VBT）后血管腔的性质尚未在临床环境中得到广泛研究。方法和结果：采用血管镜检查，对8.9 +/- 2.1个月的治疗后33例接受或不接受VBT经皮球囊血管成形术治疗的支架内再狭窄进行了随访（VBT 14病变;对照以及有红色或白色血栓的存在对照组中大多数支架（74％）被不透明的新内膜完全覆盖;相比之下，在57％的VBT病变中清楚地看到了支架撑杆。仅在29％的VBT病变中见到支杆（p = 0.03）;在对照组中未检测到支架附着不完全;而在VBT中14％的患者（p = 0.17）;在使用VBT的患者中有14％观察到红色血栓。对照组中有16％的患者表明，无论采用何种治疗方法，发生率均相似;支架撑杆暴露（p = 0.5）和支架附着不完全（p = 1.0）均与血栓无关。支架附着不完全甚至在VBT后9个月通过血管镜检查观察到支架内再狭窄的情况。

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