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首页> 外文期刊>Circulation journal >Augmentation of left ventricular apical endocardial rotation with inotropic stimulation contributes to increased left ventricular torsion and radial strain in normal subjects: quantitative assessment utilizing a novel automated tissue tracking techni
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Augmentation of left ventricular apical endocardial rotation with inotropic stimulation contributes to increased left ventricular torsion and radial strain in normal subjects: quantitative assessment utilizing a novel automated tissue tracking techni

机译：变力刺激增强左室心尖心内膜旋转有助于增加正常受试者的左心室扭转和径向张力：利用新型自动组织追踪技术进行定量评估

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BACKGROUND: The difference in the left ventricular (LV) torsion of the endo- and epicardium (Endo, Epi) with inotropic stimulation and its relation to radial strain (RS) remain unclear. METHODS AND RESULTS: LV basal and apical short-axis images were recorded in 13 normal subjects at rest and during dobutamine infusion (5, 10 microg x kg (-1) x min(-1)). A total of 8 points (anterior, lateral, posterior and septum in both Endo and Epi) were manually placed by 2-dimensional tissue tracking technique and the movement of these points during a cardiac cycle was tracked, after which the rotation angles and RS were calculated. LV torsion was defined as the net difference between the basal and apical rotations. In the LV apex, Endo-rotation increased (7.8+/-2.7 to 14.1+/-4.6 degrees, p<0.01), whereas Epi-rotation was unchanged, with dobutamine. The apical Endo-rotation was significantly greater than the Epi-rotation, although no difference was seen between the Endo and Epi in the LV base throughout the study. During dobutamine infusion, the LV Endo-torsion increased (9.5+/-2.8 to 19.3+/-4.8 degrees, p<0.01) and these values were greater than those for Epi. The apical RS increased with the dobutamine dose (39.0+/-9.3 to 61.9+/-15.5%, p<0.01), whereas basal RS initially increased at 5 microg x kg(-1) x min(-1), but thereafter showed no further increase at 10 microg x kg(-1) x min(-1) of dobutamine. CONCLUSIONS: Augmentation of LV rotation with inotropism was clearly observed in the apical Endo, thus causing increased LV endo-torsion and apical RS.
机译：背景：正性肌力刺激对内膜和心外膜（Endo，Epi）的左心室（LV）扭转的差异及其与径向应变（RS）的关系尚不清楚。方法和结果：记录了13名正常受试者在休息和多巴酚丁胺输注期间的LV基础和根尖短轴图像（5、10 microg x kg（-1）x min（-1））。通过二维组织跟踪技术手动放置了总共8个点（Endo和Epi中的前，外侧，后和隔膜），并跟踪了这些点在心动周期中的运动，之后分别确定了旋转角度和RS计算。左心室扭转定义为基础旋转和根尖旋转之间的净差。在左心尖中，多巴酚丁胺的内旋度增加（7.8 +/- 2.7至14.1 +/- 4.6度，p <0.01），而Epi旋度不变。尽管在整个研究中，LV基底的Endo和Epi之间没有差异，但根尖的Endo-rotation明显大于Epi-rotation。在多巴酚丁胺输注期间，LV内弯度增加（9.5 +/- 2.8至19.3 +/- 4.8度，p <0.01），并且这些值大于Epi值。顶峰RS随多巴酚丁胺剂量的增加而增加（39.0 +/- 9.3至61.9 +/- 15.5％，p <0.01），而基础RS最初以5 microg x kg（-1）x min（-1）升高，但此后在多巴酚丁胺10 microg x kg（-1）x min（-1）时没有进一步增加。结论：在心尖内膜明显观察到左心力增强导致左心室旋转增加，从而引起左心内膜扭转和心尖RS的增加。

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