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首页> 外文期刊>Circulation journal >Evaluation of pharmacological modulation of nitroglycerin-induced impairment of nitric oxide bioavailability by a catheter-type nitric oxide sensor.
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Evaluation of pharmacological modulation of nitroglycerin-induced impairment of nitric oxide bioavailability by a catheter-type nitric oxide sensor.

机译：通过导管型一氧化氮传感器评估硝酸甘油诱导的一氧化氮生物利用度损害的药理学调节。

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BACKGROUND: The present study aimed to elucidate the effect of long-term treatment with nitroglycerin (NTG) on the bioavailability of nitric oxide (NO) examined by a catheter-type NO sensor. The study also examined whether these effects could be modified by an antioxidant, an angiotensin converting enzyme inhibitor, or an angiotensin II type 1 receptor antagonist (ARB). METHODS AND RESULTS: Male New Zealand rabbits were treated for 7 days with NTG patches, either alone or in combination with tempol, enalapril, or valsartan (ARB). The plasma NO concentration was measured with the catheter-type NO sensor. The plasma peroxynitrite concentration was measured by enzyme-linked immunosorbent assay. An increase in plasma NO concentration in response to acetylcholine (ACh) were significantly attenuated in the NTG-treated group as compared with the control. Plasma peroxynitrite concentration in NTG-treated group was significantly higher as compared with the control. The negative effects of NTG were significantlysuppressed by the co-treatment with tempol, enalapril or valsartan. CONCLUSIONS: Chronic treatment of rabbits with NTG elicits the impairment of the ACh-stimulated NO production. In addition, the negative effects of NTG might be prevented by the co-treatment with drugs attenuating nitrosative stress.
机译：背景：本研究旨在阐明长期使用硝酸甘油（NTG）处理对通过导管式NO传感器检查的一氧化氮（NO）的生物利用度的影响。该研究还检查了这些作用是否可以通过抗氧化剂，血管紧张素转化酶抑制剂或血管紧张素II 1型受体拮抗剂（ARB）来改善。方法和结果：雄性新西兰兔单独或与tempol，enalapril或valsartan（ARB）联合使用NTG贴剂治疗7天。用导管型NO传感器测量血浆NO浓度。通过酶联免疫吸附测定法测量血浆过氧亚硝酸盐浓度。与对照组相比，在NTG治疗组中，响应于乙酰胆碱（ACh）的血浆NO浓度升高明显减弱。与对照组相比，NTG治疗组的血浆过氧亚硝酸盐浓度显着更高。与tempol，enalapril或valsartan共同治疗可显着抑制NTG的负面作用。结论：长期用NTG兔子治疗会引起ACh刺激的NO产生损伤。另外，通过与减轻亚硝化应激的药物共同治疗，可以预防NTG的负面影响。

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