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首页> 外文期刊>Circulation journal >Association between circulating monocytes and coronary plaque progression in patients with acute myocardial infarction.
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Association between circulating monocytes and coronary plaque progression in patients with acute myocardial infarction.

机译：急性心肌梗死患者循环单核细胞与冠状动脉斑块进展之间的关联。

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BACKGROUND: Monocytes and macrophages have been shown to play major roles in the progression of atherosclerosis. This study examined whether the circulating monocyte count can be used to predict coronary plaque progression of non-culprit intermediate lesions in acute myocardial infarction (AMI). METHODS AND RESULTS: Intravascular ultrasound findings of non-culprit intermediate plaque in 90 patients were analyzed in the acute phase and at a 7-month follow up. A higher peak monocyte count after AMI was associated with a greater plaque volume change (r=0.32, P=0.002). Multivariate analysis showed that a peak monocyte count of > or =800 /mm(3) was an independent predictor of plaque progression (odds ratio 5.02, P=0.005). High monocyte (> or =800 /mm(3)) at baseline had a higher monocyte count at 7-month follow up than did those with a lower count (368+/-109 vs 263+/-64 /mm(3), P<0.0001). Moreover, the monocyte count at the 7-month follow up was also associated with plaque volume change (r=0.29, P=0.006). CONCLUSIONS: The results suggest that circulating monocytes play an important role in the progression of coronary plaque in AMI and that the peak monocyte count during hospitalization might be a predictor of plaque progression.
机译：背景：单核细胞和巨噬细胞已显示在动脉粥样硬化的进展中起主要作用。这项研究检查了循环单核细胞计数是否可用于预测急性心肌梗死（AMI）中非罪犯中间病变的冠状斑块进展。方法和结果：在急性期和7个月的随访中分析了90例患者的非罪犯中间斑块的血管内超声检查结果。 AMI后较高的单核细胞峰值峰值与更大的噬斑体积变化相关（r = 0.32，P = 0.002）。多变量分析表明，单核细胞峰值>或= 800 / mm（3）是斑块进展的独立预测因子（比值比为5.02，P = 0.005）。基线时高单核细胞（>或= 800 / mm（3））在7个月的随访中比那些较低单核细胞（368 +/- 109 vs 263 +/- 64 / mm（3））高，P <0.0001）。此外，随访7个月的单核细胞计数也与斑块体积变化相关（r = 0.29，P = 0.006）。结论：结果提示循环单核细胞在急性心肌梗死斑块的进展中起着重要作用，住院期间单核细胞计数的峰值可能是斑块进展的预测指标。

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