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首页> 外文期刊>Circulation journal >Risk determinants in individuals with a spontaneous type 1 Brugada ECG.
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Risk determinants in individuals with a spontaneous type 1 Brugada ECG.

机译：自发性1型Brugada ECG个体的风险决定因素。

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BACKGROUND: Spontaneous coved ST-segment elevation >/=2 mm followed by a negative T-wave in the right precordial leads (type 1 Brugada ECG) is diagnostic of Brugada syndrome (BS), but there is a false-positive rate. METHODS AND RESULTS: Computer-processed analysis of a 12-lead ECG database containing 49,286 females and 52,779 males was performed to select patients with a spontaneous type 1 Brugada ECG for an examination of the association of this ECG characteristic with long-term prognosis. There were 185 patients with a spontaneous type 1 Brugada ECG and of these, 16 (15 males; mean age, 46.7+/-14.0 years) were diagnosed with BS and 15 patients (all males; mean age, 50.1+/-13.4 years) were undiagnosed. The PQ interval was significantly longer in the diagnosed patients than in the undiagnosed patients (187.4+/-28.3 ms vs. 161.2+/-21.5 ms; P=0.0073). The T-wave in lead V(1) was more negative in the diagnosed patients than in the undiagnosed patients (-170.2+/-174.6 microV vs. -43.2+/-122.3 microV, P=0.027). Multivariate analysis revealed that a PQ interval >/=170 ms and T-wave amplitude <105 microV in lead V(1) were independent risk stratifiers of life-threatening events. Survival analysis (mean follow-up, 78.6+/-81.8 months) showed that the PQ interval and a negative T-wave in lead V(1) were significantly associated with poor prognosis. CONCLUSIONS: Analysis of a standard 12-lead ECG can stratify the prognosis of patients with a spontaneous type 1 Brugada ECG.
机译：背景：自发性凹陷ST段抬高> / = 2 mm，右胸前导联（1型Brugada ECG）出现负T波可诊断为Brugada综合征（BS），但假阳性率较高。方法和结果：对包含49,286名女性和52,779名男性的12导联心电图数据库进行计算机分析，以选择具有自发性1型Brugada心电图的患者，以检查该心电图特征与长期预后的关系。自发性Brugada 1型心电图的患者为185名，其中16名（15名男性;平均年龄为46.7 +/- 14.0岁）被诊断为BS，另有15名患者（均为男性;平均年龄为50.1 +/- 13.4岁） ）未被诊断。被诊断的患者的PQ间隔明显长于未诊断的患者（187.4 +/- 28.3 ms与161.2 +/- 21.5 ms; P = 0.0073）。 V（1）导线中的T波在诊断出的患者中比未诊断出的患者更为阴性（-170.2 +/- 174.6 microV对-43.2 +/- 122.3 microV，P = 0.027）。多变量分析显示，铅V（1）中的PQ间隔> / = 170 ms和T波振幅<105 microV是威胁生命的独立危险因素。生存分析（平均随访时间为78.6 +/- 81.8个月）显示，铅V（1）中的PQ间隔和负T波与不良预后显着相关。结论：对标准的12导联心电图进行分析可以对自发性1型Brugada心电图患者的预后进行分层。

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