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首页> 外文期刊>Circulation journal >Prevalence and influence of hyperthyroidism on the long-term outcome of catheter ablation for drug-refractory atrial fibrillation
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Prevalence and influence of hyperthyroidism on the long-term outcome of catheter ablation for drug-refractory atrial fibrillation

机译：甲亢的发生率和对难治性心房纤颤导管消融远期疗效的影响

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Background: Hyperthyroidism is usually regarded as a reversible cause of atrial fibrillation (AF); however, one-third of patients remain in AF despite euthyroid restoration. We hypothesized that a significant number of AF patients with hyperthyroidism (Hyperthyroid-AF) as well as those without (Non-thyroid-AF) would benefit from catheter ablation of AF (AF ablation). This study aimed to clarify the prevalence of hyperthyroidism in candidates for AF ablation and to compare the long-term outcome of AF ablation between the Hyperthyroid-AF and Non-thyroid-AF groups. Methods and Results: This study enrolled 337 consecutive patients with AF who underwent a first AF ablation that mainly involved extensive encircling pulmonary vein isolation. Sixteen (4.7%) patients had hyperthyroidism; the remaining 321 (95.3%) did not. In the Hyperthyroid-AF patients, a euthyroid state had been restored for at least 3 months before the ablation. During a mean follow-up period of 4±1 years after ablation, AF recurred in 7 patients (44%) with Hyperthyroid-AF and in 139 patients (43%) with Non-thyroid-AF (P=0.91 by the log-rank test). In the multivariate Cox regression models, the presence of hyperthyroidism was not associated with a higher risk of AF recurrence (hazard ratio, 0.87; 95% confidence interval, 0.40-1.88; P=0.73). Conclusions: In the AF ablation candidates without structural heart disease, hyperthyroidism was not rare. After euthyroid restoration on pharmacological treatment, hyperthyroidism was not associated with a higher risk of AF recurrence.
机译：背景：甲亢通常被认为是房颤（AF）的可逆原因。然而，尽管甲状腺功能正常，仍有三分之一的患者仍处于房颤状态。我们假设，甲状腺功能亢进（甲状腺功能亢进）和无甲状腺功能亢进（非甲状腺功能亢进）的房颤患者中，有大量的房颤患者可以从房颤消融术中受益。本研究旨在阐明AF消融候选者中甲亢的患病率，并比较甲状腺功能亢进和非甲状腺AF组的AF消融的长期结果。方法和结果：这项研究招募了337例连续的房颤患者，他们接受了首次房颤消融，主要涉及广泛的环肺静脉隔离。甲状腺功能亢进症的患者为16名（4.7％）;其余321位（95.3％）没有。在甲状腺功能亢进型AF患者中，消融前至少3个月恢复了甲状腺功能正常。在消融后4±1年的平均随访期间，AF复发的有7例（44％）甲状腺功能亢进的AF患者和139例（43％）的非甲状腺AF患者（对数P值为0.91）等级测试）。在多元Cox回归模型中，甲亢的存在与房颤复发的风险较高无关（危险比0.87; 95％置信区间0.40-1.88; P = 0.73）。结论：在没有结构性心脏病的房颤消融患者中，甲亢并不罕见。甲状腺功能恢复正常后，甲状腺功能亢进与房颤复发的风险较高无关。

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