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首页> 外文期刊>Circulation journal >Adiponectin as a biomarker of the metabolic syndrome.
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Adiponectin as a biomarker of the metabolic syndrome.

机译：脂联素作为代谢综合征的生物标志物。

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BACKGROUND: The metabolic syndrome, a cluster of abdominal obesity, dyslipidemia, hypertension and hyperglycemia, is a common basis for atherosclerotic vascular diseases in industrial countries exposed to overnutrition. Adiponectin is an adipose-derived plasma protein with anti-atherogenic and insulin-sensitizing activities. METHODS AND RESULTS: A total of 661 Japanese adults (479 men, 53+/-10 years; 182 women 56+/-10 years) were enrolled. Plasma adiponectin concentrations correlated negatively with waist circumference, visceral fat area, serum triglyceride concentration, fasting plasma glucose, fasting plasma insulin, and systolic and diastolic blood pressure in both sexes. A positive correlation was found between plasma adiponectin and high-density lipoprotein cholesterol concentrations in both sexes. The mean number of components of the metabolic syndrome increased as the plasma adiponectin concentration decreased: 2.57+/-1.34 for men and 2.00+/-1.51 for women with adiponectin concentrations <4.0 microg/ml. In all, 52.3% of men and 37.5% of women with adiponectin concentrations <4.0 microg/ml fulfilled the criteria for metabolic syndrome. CONCLUSION: Hypoadiponectinemia is closely associated with the clinical phenotype of the metabolic syndrome and measuring the plasma concentration of adiponectin may be useful for management of the metabolic syndrome.
机译：背景：代谢综合征是一群腹部肥胖，血脂异常，高血压和高血糖症，是营养不良的工业化国家中动脉粥样硬化性血管疾病的常见基础。脂联素是具有抗动脉粥样硬化和胰岛素敏感性的脂肪来源的血浆蛋白。方法和结果：总共661名日本成年人（男性479名，年龄53 +/- 10岁;女性182名56 +/- 10岁）。血浆脂联素浓度与腰围，内脏脂肪区，血清甘油三酯浓度，空腹血浆葡萄糖，空腹血浆胰岛素以及收缩压和舒张压呈负相关。男女血浆脂联素与高密度脂蛋白胆固醇浓度之间呈正相关。随着血浆脂联素浓度的降低，代谢综合征的平均成分数增加：脂联素浓度<4.0 microg / ml的男性为2.57 +/- 1.34，女性为2.00 +/- 1.51。总的来说，脂联素浓度<4.0 microg / ml的男性中有52.3％的女性和37.5％的女性符合代谢综合征的标准。结论：低脂联素血症与代谢综合征的临床表型密切相关，测量血浆脂联素的浓度可能有助于代谢综合征的治疗。

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