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首页> 外文期刊>Journal of Advanced Physics >Effects of Electric Field on Histopathological Study, Electrical Properties and Enzymes Function of Liver of Albino Rats
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Effects of Electric Field on Histopathological Study, Electrical Properties and Enzymes Function of Liver of Albino Rats

机译：电场对白化大鼠肝脏组织病理学，电学性质和酶功能的影响

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The present work was undertaken in order to investigate the effects of electric field (EF) of strength 50 Hz-3 KV/m on the histopathology, dielectric properties and liver function tests in albino rats. Fifty male albino rats were equally divided into three groups namely A,B,and C. Animals of group A used as control group which didn't receive any treatment. Animals of group B was divided into two subgroups namely B_1 and B_2 which were discretely exposed to 50 HZ, 3 KV/m electric field for a period of 15 day (8 hours/day, 5 day/week). Group B2 animals were left to survive and housed at normal environmental conditions similar to control group A for a period of 15 day post exposed. Animals of group C are divided into two subgroups namely C_1 and C_2 were discretely exposed to the electric field for a period of 30 day (8 hours/day, 5 day/week). Group C_2 animals were left to survive and housed at normal environmental conditions similar to control group A for a period of 15 day post exposed. At the end of this period, blood and tissues samples were collected from all groups for experimental investigations. The dielectric constant (ε'), electrical conductivity (σ) was measured in frequency range 42 Hz-5 MHz to investigate any changes in liver structure through studding histopathological examination. Also, the liver function was studied through analysis of glutamic oxaloacetic transaminase (GOT), glutamic pyruvie transaminase (GPT) and total protein (TP) after exposure to electric field this biochemical parameters have been evaluated in the blood serum of rats. The obtained results show high significant changes in the value of ε' and σ of liver tissues for all groups exposed to EF as compared with control group. The levels of GOT and GPT were increased up to four times their values during the period of exposure to EF. These variations were recovered during two week after stopping exposure but they did not return to its original control values before exposure. On microscopic level; liver histological observations in liver cells which revealed some alterations including hepatic tissue with two portal tracts showing mild florous expansion and a dilated central vein, also ghosts of hepatocytes denoting necrotic changes also shows hepatic tissue with dilated central veins engorged with blood and splitting out to adjacent hepatocytes.
机译：为了研究强度为50 Hz-3 KV / m的电场（EF）对白化病大鼠的组织病理学，介电特性和肝功能测试的影响，进行了本工作。将50只雄性白化病大鼠平均分为A，B和C三组。将A组动物作为对照组，不进行任何处理。将B组的动物分为两个亚组，即B_1和B_2，将它们分别暴露于50 HZ，3 KV / m的电场下15天（8小时/天，5天/周）。使B2组动物存活并在与对照组A相似的正常环境条件下圈养15天。将C组的动物分为两个亚组，即C_1和C_2分别暴露于电场中30天（8小时/天，5天/周）。使C_2组动物存活并在与对照组A相似的正常环境条件下圈养15天。在此阶段结束时，从所有组中收集血液和组织样本用于实验研究。在42 Hz-5 MHz频率范围内测量介电常数（ε'），电导率（σ），以通过组织病理学检查研究肝脏结构的任何变化。此外，通过在接触电场后分析谷氨酸草酰乙酸转氨酶（GOT），谷氨酸丙酮酸转氨酶（GPT）和总蛋白（TP）来研究肝功能。已在大鼠的血清中评估了其生化参数。所获得的结果表明，与对照组相比，所有暴露于EF的组的肝组织ε'和σ值均具有很高的显着变化。在暴露于EF期间，GOT和GPT的水平增加到其值的四倍。这些变化在停止接触后的两周内恢复了，但在接触前未恢复到原始控制值。在微观层面上;肝细胞的肝组织学观察发现一些改变，包括具有两个门道的肝组织，显示轻度的花序扩张和中心静脉扩张，表示坏死性变化的肝细胞的鬼影也表明，具有扩张的中心静脉的肝组织充血并分裂为邻近的肝组织肝细胞。

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