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首页> 外文期刊>Journal of Advanced Computatioanl Intelligence and Intelligent Informatics >Discrete Biochemistry of DNA: Arithmetic DNA Molecules for Binary Additions, Naturally Found Genetic Logic Circuits for Plant Sensing, and DNA-Based Animation
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Discrete Biochemistry of DNA: Arithmetic DNA Molecules for Binary Additions, Naturally Found Genetic Logic Circuits for Plant Sensing, and DNA-Based Animation

机译：DNA的离散生物化学：用于二进制加成的算术DNA分子，用于植物感测的自然发现的遗传逻辑电路和基于DNA的动画

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摘要

To date, a number of researchers are seeking for and/or designing novel molecules which function as arithmetic molecular engines. Biomolecules such as deoxyribonucleic acid (DNA) and proteins are examples of promising candidate molecules. In the present article, we showed our view that DNA-based molecules could be used as a novel class of platforms for discrete mathematical operations or tools for natural computation. Here, we report on a novel molecular logic circuit combining exclusive disjunction (XOR) gate and conjunction (AND) gate implemented on a single DNA molecule performing arithmetic operations with simple binary numbers through polymerase chain reactions (PCR); which was inspired by previously developed protein-based computing model allowing simple polynomial algebra over fields through algebraic representation of cyclic inter-conversions in the catalytic modes of a plant enzyme as a cyclic additive group. In addition, we showed that DNA can be used as the platform for image coding and processing leading to DNA-coded animation by using novel PCR-based protocols. Lastly, we discussed the significance of recent attempts in the stream of natural computing and synthetic biological research, by handling DNA and related biomolecules as the media for discrete mathematical operations.
机译：迄今为止，许多研究人员正在寻找和/或设计起算术分子引擎作用的新型分子。脱氧核糖核酸（DNA）和蛋白质等生物分子是有前途的候选分子的例子。在本文中，我们展示了我们的观点，即基于DNA的分子可用作离散数学运算或自然计算工具的新型平台。在这里，我们报道了一种新颖的分子逻辑电路，该电路结合了在单个DNA分子上实现的异或门（XOR）和结（AND）门，并通过聚合酶链反应（PCR）以简单的二进制数执行算术运算;这是受先前开发的基于蛋白质的计算模型的启发，该模型允许通过以植物酶作为循环添加基团的催化模式进行循环相互转化的代数表示，在域上实现简单的多项式代数。此外，我们证明了通过使用新颖的基于PCR的协议，DNA可以用作图像编码和处理的平台，从而导致DNA编码的动画。最后，我们通过处理DNA和相关生物分子作为离散数学运算的媒介，讨论了自然计算和合成生物学研究中最近尝试的意义。

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