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首页> 外文期刊>Journal of aerosol medicine and pulmonary drug delivery >Electrostatic charge characteristics of jet nebulized aerosols
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Electrostatic charge characteristics of jet nebulized aerosols

机译：喷射雾化气溶胶的静电特性

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Background: Liquid droplets can be spontaneously charged in the absence of applied electric fields by spraying. It has been shown by computational simulation that charges may influence particle deposition in the airways. The electrostatic properties of jet nebulized aerosols and their potential effects on lung deposition have hardly been studied. A modified electrical low pressure impactor (ELPI) was employed to characterize the aerosol charges generated from jet nebulized commercial products. Methods: The charge and size measurements were conducted at 50% RH and 22°C with a modified ELPI. Ventolin?, Bricanyl?, and Atrovent? were nebulized using PARI LC? Plus jet nebulizers coupled to a DeVilbiss Pulmo-Aide? compressor. The aerosols were sampled in 30-sec durations. The drug deposits on the impactor stages were assayed chemically using high-performance liquid chromatography (HPLC). The charges of nebulized deionized water, isotonic saline, and the three commercial products diluted with saline were also measured to analyze the contributions of the major nebule ingredients on charging. No mass assays were performed on these runs. Results: All three commercial nebules generated net negative charges. The magnitude of the charges reduced over the period of nebulization. Ventolin? and Bricanyl? yielded similar charge profiles. Highly variable charges were produced from deionized water. On the other hand, nebulized saline reproducibly generated net positive charges. Diluted commercial nebules showed charge polarity inversion. The charge profiles of diluted salbutamol and terbutaline solutions resembled those of saline, while the charges from diluted ipratropium solutions fluctuated near neutrality. Conclusions: The charge profiles were shown to be influenced by the concentration and physicochemical properties of the drugs, as well as the history of nebulization. The drugs may have unique isoelectric concentrations in saline at which the nebulized droplets would carry near-zero charges. According to results from computational simulation models in the literature, the numbers of elementary charges per droplet estimated from the data were not high enough to potentially affect lung deposition.
机译：背景：在没有施加电场的情况下，可以通过喷雾使液滴自发带电。计算仿真表明，电荷可能会影响气道中的颗粒沉积。几乎没有研究过喷射雾化气溶胶的静电特性及其对肺部沉积的潜在影响。使用改进的低压电子冲击器（ELPI）来表征由喷射雾化的商业产品产生的气溶胶装料。方法：使用改良的ELPI在50％RH和22°C下进行电荷和尺寸测量。 Ventolin？，Bricanyl？和Atrovent？使用PARI LC雾化？再加上与DeVilbiss Pulmo-Aide相连的喷射雾化器？压缩机。以30秒的持续时间对气溶胶采样。使用高效液相色谱（HPLC）化学分析了撞击器级上的药物沉积物。还测量了雾化的去离子水，等渗盐水以及用盐水稀释的三种商品的电荷，以分析主要的星云成分对电荷的贡献。在这些运行中未进行质量测定。结果：所有三个商业星云均产生净负电荷。在雾化期间，电荷量减小。文图林？和Bricanyl？产生相似的电荷分布。用去离子水产生高度可变的电荷。另一方面，雾化的盐水可再现地产生净正电荷。稀释的商业星云显示出电荷极性反转。稀释的沙丁胺醇和特布他林溶液的电荷分布类似于盐水，而稀异丙托铵溶液的电荷则在中性附近波动。结论：电荷分布受药物浓度，理化性质以及雾化历史的影响。药物在盐水中可能具有独特的等电浓度，在该浓度下，雾化的液滴将携带接近零的电荷。根据文献中的计算仿真模型的结果，从数据估计的每个液滴基本电荷数量不足以潜在地影响肺部沉积。

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