• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of aerosol medicine and pulmonary drug delivery >Aerosol Therapy in Adults Receiving High Flow Nasal Cannula Oxygen Therapy
【24h】

Aerosol Therapy in Adults Receiving High Flow Nasal Cannula Oxygen Therapy

机译：成人接受高流量鼻导管氧气疗法的气雾疗法

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: High flow nasal cannula oxygen therapy (HFT) is increasingly used in intensive and emergency care departments. Patients suffering from respiratory failure, who are likely to benefit from HFT, may require aerosolized bronchodilators; therefore, combining nebulization with HFT may be relevant. This study aimed to identify the optimal settings for the implementation of nebulization within an adult HFT circuit. Methods: We assessed the mass and the particle size distribution of the aerosol emitted from the nasal cannula (inhalable mass) using mesh- and jet-nebulizers placed at various positions in the HFT circuit. Thereafter, the most relevant combination was used to evaluate the mass of salbutamol delivered downstream of an anatomical model reproducing aerosol deposition and leakage at the nasal and pharyngeal levels (respirable mass). The influence of HFT flow rate (30, 45, and 60L/min), of breathing pattern (quiet and respiratory distress pattern) as well as of opened and closed mouth breathing was assessed. Results: The most efficient position was that of a nebulizer placed upstream from the humidification chamber (inhalable mass ranging from 26% to 32% of the nebulizer charge). Using a mesh nebulizer, we observed a respirable mass ranging from 2% to 10% of the nebulizer charge. Higher HFT flow rates and open mouth breathing were associated with a lower efficiency. Simulating respiratory distress (i.e., increasing the simulated patient inspiratory flow) did not hamper drug delivery as compared to a quiet breathing pattern. Conclusions: Placing nebulizers within a HFT circuit upstream from the humidification chamber may enable to deliver clinically relevant masses of aerosol at the cannula outlet, but more importantly downstream of the nose and pharynx, even in case of high patients' inspiratory flow. This method of aerosol therapy is expected to produce a bronchodilatatory effect to be evaluated in the clinical settings.
机译：背景：重症监护和急诊科越来越多地使用高流量鼻导管氧疗（HFT）。可能受益于HFT的呼吸衰竭患者可能需要雾化的支气管扩张剂;因此，将雾化与HFT结合可能是有意义的。这项研究旨在确定在成人HFT电路中实施雾化的最佳设置。方法：我们使用放置在HFT回路中各个位置的网状喷雾器和喷射雾化器，评估了从鼻导管散发的气溶胶的质量和粒径分布（可吸入质量）。此后，最相关的组合用于评估在鼻和咽水平产生气溶胶沉积和渗漏的解剖模型下游递送的沙丁胺醇的质量（可吸入质量）。评估了HFT流速（30、45和60L / min），呼吸方式（安静和呼吸窘迫方式）以及张口和闭口呼吸的影响。结果：最有效的位置是将雾化器放置在加湿室的上游（可吸入质量为雾化器装料量的26％至32％）。使用网状雾化器，我们观察到可吸入质量为雾化器装药量的2％至10％。较高的HFT流量和张口呼吸与较低的效率相关。与安静的呼吸模式相比，模拟呼吸窘迫（即增加模拟的患者吸气流量）不会妨碍药物输送。结论：将雾化器放置在加湿室上游的HFT回路中可以使临床上相关的气雾物质在插管出口处，但更重要的是在鼻子和咽部的下游传递，即使在患者吸气流量较高的情况下。预期该气雾疗法的方法会产生支气管扩张作用，并将在临床环境中进行评估。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号