ADAM10-Dependent Signaling Through Notchl and Notch4 Controls Development of Organ-Specific Vascular Beds

Alabi Rolake O.; Glomski Krzysztof; Haxaire Coline; Weskamp Gisela; Monette Sebastien; Blobel Carl P.

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ADAM10-Dependent Signaling Through Notchl and Notch4 Controls Development of Organ-Specific Vascular Beds

机译：通过Notch1和Notch4依赖ADAM10的信号控制了器官特异性血管床的发育

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Rationale: Endothelial Notch signaling is critical for early vascular development and survival. Yet, previously described mice lacking endothelial a disintegrin and metalloproteinase 10 (ADAM10), a key regulator of Notch signaling, survived into adulthood with organ-specific vascular defects. These findings raised questions about whether these vascular defects were related to Notch signaling or other functions of ADAM10.

机译：理由：内皮Notch信号对于早期血管发育和生存至关重要。然而，先前描述的小鼠缺乏内皮整合素和金属蛋白酶10（ADAM10）（Notch信号的关键调节因子）存活至成年后出现器官特异性血管缺陷。这些发现引起了关于这些血管缺陷是否与Notch信号传导或ADAM10的其他功能有关的疑问。

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《Circulation research: a journal of the American Heart Association》 |2016年第4期|共55页
作者
Alabi Rolake O.; Glomski Krzysztof; Haxaire Coline; Weskamp Gisela; Monette Sebastien; Blobel Carl P.;
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正文语种 eng
中图分类心脏、血管（循环系）疾病;
关键词
bone development; disintegrins; embryonic development endothelial cells; phenotype; transgenes;

机译：骨骼发育;整联蛋白;胚胎发育内皮细胞;表型;转基因;

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2. ADAM10-Dependent Signaling Through Notchl and Notch4 Controls Development of Organ-Specific Vascular Beds [J] . Alabi Rolake O., Glomski Krzysztof, Haxaire Coline, Circulation research: a journal of the American Heart Association . 2016,第4期

机译：通过Notch1和Notch4依赖ADAM10的信号控制了器官特异性血管床的发育
3. Intriguing Roles for Endothelial ADAM10/Notch Signaling in the Development of Organ-Specific Vascular Beds. [J] . Rolake O Alabi, Gregory Farber, Carl P Blobel Physiological Reviews . 2018,第4期

机译：内皮ADAM10 / NOTCH信号传导在器官特异性血管床中的引发作用。
4. MicroRNA control of vascular endothelial growth factor signaling output during vascular development [J] . DangL.T.H., LawsonN.D., FishJ.E. Arteriosclerosis, thrombosis, and vascular biology . 2013,第2期

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5. Minimal-Dose Cancer Chemotherapy: Anti-Cancer Drugs Loaded Nanodevices towards Time, Site Organ-Specific Releases for Development of Personalized Nanomedicine [C] . Riaz A. Khan, Shilpa J. Newati, Varsha M. Singh, NSTI-Nanotech 2010;NSTI nanotechnology conference and expo;Bio Nanotech 2010;NSTI bio nano conference and expo;Microtech 2010;Microtechnology conference and expo;WCM 2010;Workshop on compact modeling;NSTI nanotech ventures;TechConnect summit;Clean technology . 2010

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6. Norrin, Frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization. [D] . Ye, Xin. 2010

机译：内皮细胞中的Norrin，Frizzled-4和Lrp5信号控制着视网膜血管化的遗传程序。
7. ADAM10-Dependent Signaling Through Notch1 and Notch4 Controls Development of Organ-Specific Vascular Beds [O] . Rolake O. Alabi, Krzystof Glomski, Coline Haxaire, -1

机译：通过Notch1和Notch4依赖ADAM10的信号控制了器官特异性血管床的发育
8. Intriguing Roles for Endothelial ADAM10/Notch Signaling in the Development of Organ-Specific Vascular Beds [O] . Rolake O. Alabi, Gregory Farber, Carl P. Blobel 2018

机译：用于内皮ADAM10 / NOTCH信号传导在器官特异性血管床中的兴趣作用

ADAM10-Dependent Signaling Through Notchl and Notch4 Controls Development of Organ-Specific Vascular Beds

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