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首页> 外文期刊>Journal of aerosol medicine and pulmonary drug delivery >Intranasal Deposition of Accuspray (TM) Aerosol in Anatomically Correct Models of 2-, 5-, and 12-Year-Old Children
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Intranasal Deposition of Accuspray (TM) Aerosol in Anatomically Correct Models of 2-, 5-, and 12-Year-Old Children

机译：在2岁，5岁和12岁儿童的解剖学正确模型中进行Accuspray（TM）气雾剂的鼻内沉积

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Background: To our knowledge, quantification of intranasal deposition of aerosol generated by Accuspray (AS) in children has never been published. We hypothesized that deposition would vary significantly with age and with placement of the device within, or outside, of the nostril. Methods: We tested these hypotheses in anatomically-correct physical models based on CT scans of 2-, 5-, and 12-year-old children with normal, intranasal airways. Models included a removable anterior nose (AN) with exterior facial features and interior nasal vestibule and nasal valve area and a main nasal airway (MNA), subdivided into upper (superior turbinates and olfactory area), middle (middle turbinates), and lower (inferior turbinates and nasopharynx) thirds. Aerosol was generated from distilled water admixed with (99m)technetium pertechnetate and administered during static airflow by AS inserted inside the right nostril (eight runs/model), or outside the right nostril (six runs/model). Mean aerosol Dv(50)standard deviation was 67.824.7m. Deposition was quantified by 2D gamma scintigraphy and expressed as percentage of the emitted dose. Results: When placed inside the nostril, mean (+/- standard deviation) deposition within the MNA was significantly less in the 2-year-old, compared to the 5- and 12-year-old, averaging 46.8 +/- 33.8% (AN:55.4 +/- 29.9%), 75.4 +/- 26.7% (AN:23.3 +/- 13.6%), and 72.1 +/- 18.5% (AN:25.8 +/- 18.5%), respectively (p<0.05). When placed outside the nostril, MNA was significantly less in the 2- and 5-year-old compared to the 12-year-old, with 1.4 +/- 2.5% (AN:69.7 +/- 40.7%), 7.4 +/- 9.0% (AN:77.8 +/- 32.8%), and 21.1 +/- 29.1% (AN:29.2 +/- 19.3%), respectively (p<0.05). Deposition in the MNA of all age models was highest when AS was placed inside the nostril (p<0.05). Deposition in the lower third was significantly increased for the 5- and 12-year-old and in the middle third of the 5-year-old when AS was placed inside the nostril. Conclusions: These results indicate that age and device placement play important roles in terms of intranasal deposition, when administering aerosol with Accuspray to children.
机译：背景：据我们所知，Accuspray（AS）在儿童中鼻内气溶胶沉积的定量研究尚未发表。我们假设沉积物会随着年龄的增长以及装置在鼻孔内或外的变化而显着变化。方法：我们根据2岁，5岁和12岁正常鼻内呼吸道儿童的CT扫描，在解剖学上正确的物理模型中测试了这些假设。模型包括可移除的前鼻孔（AN），具有外部面部特征，内部鼻前庭和鼻瓣区域以及主要的鼻气道（MNA），分为上层（上鼻甲和嗅觉区域），中层（中鼻甲）和下层（鼻甲）下鼻甲和鼻咽）。气雾剂是由蒸馏水和​​高tech酸（99m）ad混合而成，并在静态气流过程中通过插入右鼻孔（八个管路/型号）或右鼻孔（六个管路/型号）内的AS进行管理。气溶胶Dv（50）的平均标准偏差为67.824.7m。沉积通过2D伽玛闪烁显像定量，并表示为发射剂量的百分比。结果：当放置在鼻孔内时，与5岁和12岁相比，2岁的MNA内平均（+/-标准偏差）沉积明显减少，平均为46.8 +/- 33.8％ （AN：55.4 +/- 29.9％），75.4 +/- 26.7％（AN：23.3 +/- 13.6％）和72.1 +/- 18.5％（AN：25.8 +/- 18.5％）（p < 0.05）。当放置在鼻孔外时，2岁和5岁儿童的MNA明显低于12岁儿童，分别为1.4 +/- 2.5％（AN：69.7 +/- 40.7％），7.4 +/- -分别为9.0％（AN：77.8 +/- 32.8％）和21.1 +/- 29.1％（AN：29.2 +/- 19.3％）（p <0.05）。当将AS放置在鼻孔内时，所有年龄模型的MNA中的沉积最高（p <0.05）。当将AS放置在鼻孔中时，5岁和12岁的儿童的下三分之一的沉积显着增加，而5岁的中三分之一的儿童的沉积明显增加。结论：这些结果表明，将Accuspray气雾剂用于儿童时，年龄和装置放置在鼻内沉积方面起着重要作用。

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