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首页> 外文期刊>Journal of Analytical Toxicology >Distribution of butalbital in postmortem tissues and fluids from non-overdose cases.
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Distribution of butalbital in postmortem tissues and fluids from non-overdose cases.

机译：非用药过量病例在尸体组织和体液中丁醛的分布。

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摘要

During the investigation of fatal aviation accidents, postmortem samples from the pilots/co-pilots are submitted to the Federal Aviation Administration's (FAA) Civil Aerospace Medical Institute (CAMI) for toxicological analysis. Although therapeutic levels for most drugs are typically reported in the scientific literature for blood and plasma, blood specimens are received in only approximately 70% of our cases. Therefore, it is imperative for an accident investigator and forensic toxicologist to be able to estimate drug concentrations in an aviation accident victim's blood from available tissue drug concentrations. This is exemplified by a recent aviation fatality in which butalbital was identified in the muscle tissue of a pilot. In this case, no blood was available for analysis, but investigators needed to know the approximate butalbital concentration expected in the victim's blood. Certain side effects of butalbital, such as drowsiness, sedation, dizziness, and a feeling of intoxication, could affect pilot performance and become a significant factor in an aviation accident. Thus, our laboratory determined the distribution of butalbital in various postmortem tissues and fluids. The distribution coefficients for butalbital, expressed as specimen/blood ratios, were found to be as follows: 0.66 +/- 0.09 (muscle, n = 4), 0.98 +/- 0.09 (kidney, n = 4), 0.87 +/- 0.06 (lung, n = 4), 0.75 +/- 0.03 (spleen, n = 4), 0.96 +/- 0.07 (brain, n = 3), 2.22 +/- 0.04 (liver, n = 4), and 0.91 +/- 0.17 (heart, n = 2). The results obtained from our limited number of cases suggest that muscle, kidney, lung, spleen, brain, liver, and heart could be used, in a cautious and conservative fashion, to estimate butalbital blood concentrations.
机译：在致命航空事故调查期间，将飞行员/副驾驶员的尸体样本送交联邦航空管理局（FAA）的民航医学研究所（CAMI）进行毒理学分析。尽管在科学文献中通常会针对血液和血浆报告大多数药物的治疗水平，但仅在我们病例的70％中收到了血液标本。因此，事故调查人员和法医毒物学家必须能够根据可用的组织药物浓度估算航空事故受害人血液中的药物浓度。最近发生的航空事故就是一个例子，其中在飞行员的肌肉组织中发现了丁比妥。在这种情况下，没有血液可用于分析，但是研究人员需要知道受害者血液中预期的近似丁比妥浓度。嗜睡，镇静，头晕和陶醉感等丁巴比妥的某些副作用可能会影响飞行员的表现，并成为航空事故的重要因素。因此，我们的实验室确定了各种验尸组织和体液中丁比妥的分布。发现以标本/血比表示的丁烷分配系数如下：0.66 +/- 0.09（肌肉，n = 4），0.98 +/- 0.09（肾脏，n = 4），0.87 +/- 0.06（肺，n = 4），0.75 +/- 0.03（脾，n = 4），0.96 +/- 0.07（脑，n = 3），2.22 +/- 0.04（肝，n = 4）和0.91 +/- 0.17（心脏，n = 2）。从我们有限的病例中获得的结果表明，可以谨慎和保守的方式使用肌肉，肾脏，肺，脾脏，大脑，肝脏和心脏来估计丁比尔血药浓度。

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