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首页> 外文期刊>Journal of Analytical Toxicology >Redistribution of diltiazem in the early postmortem period.
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Redistribution of diltiazem in the early postmortem period.

机译：地尔硫卓在死后的早期重新分布。

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摘要

We determined tissue distribution of diltiazem after it was used to treat hypertension in two cases. The postmortem interval was 16 h in both cases. Diltiazem was isolated using liquid-liquid extraction, and it was identified and quantitated using gas chromatography-mass spectrometry (GC-MS) and GC, respectively. In one case, diltiazem concentrations in the lungs and pulmonary vessel blood were 62-82 and 27-30 times higher than right femoral blood, respectively. Although blood was not obtained from the left cardiac chambers, aortic blood showed a 10-times higher level of diltiazem than right femoral venous blood. Diltiazem concentration in blood in the right cardiac chambers was 3.6 times higher than that in right femoral venous blood. In another case, diltiazem concentrations in the lungs were 7.4-7.6 times higher than right femoral venous blood. Blood in the pulmonary arteries, pulmonary veins, left cardiac chambers, and aorta showed 2.0-3.1 times higher levels of diltiazem than right femoral venous blood. Blood in the right cardiac chambers displayed only 1.3 times higher level of diltiazem than right femoral venous blood. Our results strongly suggest that diltiazem accumulated in the lungs and was rapidly redistributed into pulmonary venous blood and then into the left cardiac chambers.
机译：我们确定了地尔硫卓在用于治疗高血压的两例患者中的组织分布。两种情况下的死后间隔均为16小时。使用液-液萃取法分离地尔硫卓，并分别使用气相色谱-质谱（GC-MS）和GC对其进行鉴定和定量。在一种情况下，肺和肺血管血液中地尔硫卓的浓度分别比右股血高62-82和27-30倍。尽管没有从左心房获得血液，但主动脉血中的地尔硫卓水平却是右股静脉血的10倍。右心室血液中地尔硫卓的浓度是右股静脉血液中地尔硫卓的3.6倍。在另一种情况下，肺中地尔硫卓的浓度比右股静脉血高7.4-7.6倍。肺动脉，肺静脉，左心房和主动脉中的血液显示出地尔硫卓的水平是右股静脉血液的2.0-3.1倍。右心室的血液中地尔硫卓的水平仅比右股静脉的血液高1.3倍。我们的结果强烈表明地尔硫卓在肺中积累，并迅速重新分布到肺静脉血中，然后再分布到左心室中。

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