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首页> 外文期刊>Journal of Analytical Toxicology >Nail and bone surface as biomarkers for acute fluoride exposure in rats.
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Nail and bone surface as biomarkers for acute fluoride exposure in rats.

机译：指甲和骨骼表面是大鼠急性氟化物暴露的生物标志物。

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摘要

When acute exposure to fluoride is thought to be the cause of death, confirmation often depends on the analysis of some body fluid or tissue. The aim of this study was to evaluate the use of nails and the periosteal surface of bone as indicators of acute exposure to fluoride. Six groups of rats were given a single oral dose of fluoride (50 mg/kg body weight), while the control group was given deionized water. The rats were killed at 2, 4, 8, 16, 24, and 48 h after fluoride administration. Plasma and nails (the proximal halves) were collected and analyzed for fluoride with an ion-specific electrode after hexamethyldisiloxane-facilitated diffusion. A circular area of the femur (4.52 mm(2)) was etched with 0.5M HCl for 15 s, and, after the addition of a buffer, the solution was analyzed with an ion-specific electrode. Peak plasma concentration occurred at 2 h, followed by progressively declining concentrations. Peak nail fluoride concentrations occurred at 8 h. The mean nail concentrations at 8, 16, and 24 h were significantly higher than that of the control group. Bone surface concentrations were significantly higher than that of the control group at 4 h and thereafter. Thus, the proximal portion of nails and bone surface are suitable biomarkers for acute fluoride exposure in rats.
机译：当认为急性暴露于氟化物是导致死亡的原因时，确认通常取决于对某些体液或组织的分析。这项研究的目的是评估指甲和骨骨膜表面作为急性暴露于氟化物的指标的用途。六组大鼠口服单剂量的氟化物（50 mg / kg体重），而对照组则接受去离子水。氟化物施用后2、4、8、16、24和48小时处死大鼠。收集血浆和指甲（近端的两半），并在六甲基二硅氧烷促进扩散后用离子专用电极分析氟化物。用0.5M HCl蚀刻股骨的圆形区域（4.52 mm（2））15 s，添加缓冲液后，用离子特异性电极分析溶液。血浆峰值浓度在2 h出现，然后浓度逐渐下降。指甲氟化物的峰值浓度出现在8小时。在8、16和24 h时，指甲的平均浓度显着高于对照组。在4小时及之后，骨表面浓度显着高于对照组。因此，指甲的近端部分和骨骼表面是大鼠急性氟化物暴露的合适生物标记。

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