...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Analytical Toxicology >Detection of cannabis use in drivers with the drugwipe device and by GC-MS after Intercept device collection.
【24h】

Detection of cannabis use in drivers with the drugwipe device and by GC-MS after Intercept device collection.

机译：在Intercept设备收集后，通过药擦设备和GC-MS检测驾驶员使用的大麻。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Saliva or "oral fluid" has been presented as an alternative matrix in the establishment of drug exposure. The noninvasive collection of a saliva sample, which is relatively easy to perform and can be achieved under close supervision, is one of the most important benefits in a driving under the influence situation. Moreover, the presence of delta9-tetrahydrocannabinol (THC) in oral fluid is a better indication of recent use than when the drug is detected in urine, so there is a higher probability that the subject is experiencing pharmacological effects at the time of sampling. At 3 check points organized by the Swiss police in Bern, 61 drivers were tested for the presence of drugs of abuse using the Drugwipe 5 device. In parallel, oral fluid was collected with the Intercept DOA Oral Specimen Collection device and tested by gas chromatography-mass spectrometry (GC-MS) after methylation of THC (limit of quantitation 1 ng/mL). The Drugwipe device identified 1 exposed driver, but with GC-MS, 18 drivers tested positive. THC concentrations in the Intercept buffer ranged from 2.1 to 205.1 ng/mL. These concentrations represent about 1/2 to 1/3 the authentic THC concentrations in oral fluid because of the dilution by the blue liquid of the device. Two main limitations of oral fluid were 1. the amount of matrix collected is smaller when compared to urine and 2. the levels of drugs in urine are higher than in oral fluid. A current limitation of the use of this specimen for roadside testing is the absence of a suitable immunoassay that detects the parent compound in sufficiently low concentrations.
机译：唾液或“口腔液”已被提出作为建立药物暴露的替代基质。唾液样品的非侵入性采集相对容易执行，并且可以在密切监督下完成，这是在影响情况下驾驶的最重要好处之一。此外，与在尿液中检测到药物相比，口腔液中存在delta9-四氢大麻酚（THC）更好地表明了近期使用的情况，因此，在采样时受试者出现药理作用的可能性更高。在瑞士警察在伯尔尼组织的3个检查站，使用Drugwipe 5设备对61名驾驶员进行了滥用药物测试。平行地，在THC甲基化后（定量限1 ng / mL），用Intercept DOA口腔样本收集装置收集口腔液，并通过气相色谱-质谱法（GC-MS）进行测试。 Drugwipe设备识别出1个暴露的驱动程序，但是使用GC-MS，有18个驱动程序测试为阳性。 Intercept缓冲液中的THC浓度范围为2.1至205.1 ng / mL。由于该装置的蓝色液体稀释，这些浓度代表口腔液中真实THC浓度的约1/2至1/3。口服液的两个主要局限性是：1.与尿液相比，收集的基质量少; 2.尿液中的药物含量高于口服液。该标本在路边测试中使用的当前局限性是缺乏合适的免疫分析方法，该方法无法检测到足够低浓度的母体化合物。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号