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首页> 外文期刊>Journal of Analytical Toxicology >Occupational exposure to methamphetamine in workers preparing training AIDS for drug detection dogs.
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Occupational exposure to methamphetamine in workers preparing training AIDS for drug detection dogs.

机译：为药物侦查犬准备培训艾滋病的工作人员职业接触甲基苯丙胺。

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As a part of ongoing testing of personnel preparing training aids for drug detection dogs at the Naval Criminal Investigative Service Regional Forensic Laboratory, personnel handling methamphetamine (MTH) were subject to voluntary urine drug testing. This provided a model of potential unwitting or environmental exposure contribution to MTH concentrations in urine. Urine samples were collected from multiple individuals on the day before, the day of, and the day after the individuals had handled up to 500-g quantities of MTH during the assembly of training aids. Personnel wore gloves, dust masks, and lab coats during the preparation of training aids. A total of 101 urine samples were analyzed for the presence of MTH and amphetamine (AMP) by gas chromatography-mass spectrometry after solid-phase extraction and derivatization. Urine samples collected during and after personnel handled drug yielded a mean MTH concentration of 48 ng/mL with a maximum concentration of 262 ng/mL and a minimum detected concentration of approximately 1.6 ng/mL. Thirty-five of the 52 post drug-handling samples had detectable MTH. Ten of the samples had MTH concentrations above the method limit of quantitation of 15 ng/mL. Only one sample had a concentration greater than 50 ng/mL. None of the samples had detectable AMP. From this limited study, it was evident that handling of MTH under these conditions resulted in minimal exposure and small but detectable concentrations of MTH in urine.
机译：作为在海军犯罪调查局地区法医实验室对准备用于毒品侦查犬的训练辅助工具的人员进行持续测试的一部分，处理甲基苯丙胺（MTH）的人员将接受自愿尿液药物测试。这提供了潜在的不知情或环境暴露对尿液中甲状旁腺激素浓度贡献的模型。在组装助教期间，在多个个体处理了多达500克MTH的前一天，后一天和后一天，从多个个体收集了尿液样本。在准备训练教具时，人员要戴手套，防尘口罩和实验室大衣。在固相萃取和衍生化之后，通过气相色谱-质谱法分析了总共101个尿液样品中的甲硫氨酸和苯丙胺（AMP）的存在。在人员处理药物期间和之后收集的尿液样品的平均甲状旁腺激素浓度为48 ng / mL，最大浓度为262 ng / mL，最小检出浓度为约1.6 ng / mL。 52个药物处理后样本中有35个具有可检测的MTH。十个样品的MTH浓度超过了15 ng / mL的定量方法极限。只有一个样品的浓度大于50 ng / mL。所有样品均未检测到AMP。从这项有限的研究中，很明显在这些条件下处理MTH可使尿液中MTH的暴露量降至最低，并检测出少量但可检测的MTH浓度。

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