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首页> 外文期刊>Journal of Analytical Toxicology >Determination of mercury in whole blood and urine by inductively coupled plasma mass spectrometry.
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Determination of mercury in whole blood and urine by inductively coupled plasma mass spectrometry.

机译：电感耦合等离子体质谱法测定全血和尿液中的汞。

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摘要

The conventional method for the determination of mercury in clinical samples is cold vapor atomic absorption spectrometry. Sample digestion or pretreatment require large sample volume and long sample preparation time. The inductively coupled plasma mass spectrometry (ICP-MS) method developed in this study requires only 100 microL of sample with practically no preparation, except for dilution with diluent. Significant savings in sample volumes, reagents, technician time, and analysis time are realized. Among different types of diluents, the one containing acid, tert-butanol, and potassium dichromate gave the best results to remove the mercury memory effect. The interassay precisions for whole blood and urine were < 5% and < 8%, respectively, and the intra-assay precisions were < 3% and < 7%, respectively. The lower limits of detection were 0.13, 0.17, and 0.26 microg/L for aqueous standard, urine, and whole blood, respectively. The developed ICP-MS method correlated well with the atomic absorption method and can offer an alternative to the atomic absorption method for mercury analysis with less sample volume requirement as well as shorter analysis time.
机译：测定临床样品中汞的常规方法是冷蒸气原子吸收光谱法。样品的消化或预处理需要大量的样品和较长的样品制备时间。本研究中开发的电感耦合等离子体质谱法（ICP-MS）仅需要100微升样品，几乎没有制备方法，只是用稀释剂稀释。大大节省了样品量，试剂，技术人员时间和分析时间。在不同类型的稀释剂中，包含酸，叔丁醇和重铬酸钾的稀释剂在去除汞存储效果方面效果最佳。全血和尿液的测定间精密度分别为<5％和<8％，测定内精确度分别为<3％和<7％。水性标准液，尿液和全血的最低检测限分别为0.13、0.17和0.26 microg / L。所开发的ICP-MS方法与原子吸收法密切相关，可以为汞分析提供原子吸收法的替代方法，其样品体积要求更少，分析时间也更短。

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