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首页> 外文期刊>Journal of Analytical Toxicology >Serum levels of olanzapine in a non-fatal overdose.
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Serum levels of olanzapine in a non-fatal overdose.

机译：非致命过量的奥氮平血清水平。

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摘要

Olanzapine is a widely used second generation antipsychotic drug. Case reports of intoxications have been published, but reports in the literature of non-fatal intoxications of olanzapine containing repeated measurements of serum levels are scarce. Therefore, this case of non-fatal olanzapine intoxication is presented, in which 19 blood samples were drawn during 2 weeks. The highest (initial) measured value was estimated at 800 pg/L. This patient ingested 550 mg of olanzapine resulting in clinical signs of intoxication, including seizures. Because the patient was found the day after the intoxication, the initial concentration had probably been higher. The pharmacokinetics of olanzapine has been described as linear and dose-proportional throughout the therapeutic dosing range. Large overdoses, however, have been described to show non-linear pharmacokinetics. In this study's series of serum concentrations, a two-phase elimination was seen, with an initial elimination half-life of about 24 h during the first 3 days, followed by a second phase with a half-life of about 2.5 days. The patient in this case recovered completely. Because the elimination time after intoxication can be considerably longer than expected, it is recommended that the patient's serum concentrations after intoxication be monitored.
机译：奥氮平是一种广泛使用的第二代抗精神病药。中毒的病例报告已经发表，但文献中缺乏重复测量血清水平的奥氮平非致命性中毒的报道。因此，提出了这种非致命性奥氮平中毒的案例，其中在2周内抽取了19个血液样本。最高（初始）测量值估计为800 pg / L。该患者摄入550毫克的奥氮平，导致中毒的临床征象，包括癫痫发作。因为在中毒的第二天就发现了患者，所以最初的浓度可能更高。在整个治疗剂量范围内，奥氮平的药代动力学被描述为线性且与剂量成比例。然而，已经描述了大剂量用药以显示非线性药代动力学。在该研究的一系列血清浓度中，观察到两阶段消除，在最初的3天中初始消除半衰期约为24小时，随后是第二阶段，其半衰期约为2.5天。在这种情况下，病人完全康复了。由于中毒后的消除时间可能比预期的要长得多，因此建议监测中毒后患者的血清浓度。

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