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首页> 外文期刊>Journal of Analytical Toxicology >Interindividual variability in the prevalence of OPRM1 and CYP2B6 gene variations may identify drug-susceptible populations.
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Interindividual variability in the prevalence of OPRM1 and CYP2B6 gene variations may identify drug-susceptible populations.

机译：OPRM1和CYP2B6基因变异发生率的个体间差异可能会确定药物易感人群。

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摘要

Methadone is used worldwide for the treatment of heroin addiction; however, fatal poisonings are increasingly reported. The prevalence of CYP2B6 and mu-opioid receptor (OPRM1) gene variations were examined between a postmortem population where the deaths were associated with methadone and a live nondrug-using control population using Taqman SNP Genotyping assays. The CYP2B6*6 allele was higher in the postmortem population, but the difference was not significant (P = 0.92). The CYP2B6 T750C promoter variation was similar in frequency for both populations. Linkage between T750C and CYP2B6*6 was identified for both populations (P < 0.01). The prevalence of the OPRM1 A118G variation was significantly higher in the control population (P = 0.0046), which might indicate a protective mechanism against opioid toxicity. Individual susceptibility to methadone may be determined by screening for CYP2B6*6.
机译：美沙酮在世界范围内用于治疗海洛因成瘾;但是，致命中毒的报道越来越多。使用Taqman SNP基因分型分析法检测了死亡与美沙酮相关的死后人群与活的非吸毒对照人群之间的CYP2B6和mu阿片受体（OPRM1）基因变异的发生率。 CYP2B6 * 6等位基因在死后人群中较高，但差异不显着（P = 0.92）。两种人群的CYP2B6 T750C启动子变异的频率相似。两种人群的T750C和CYP2B6 * 6之间均存在关联（P <0.01）。对照人群中OPRM1 A118G变异的患病率显着更高（P = 0.0046），这可能表明有针对阿片类药物毒性的保护机制。个体对美沙酮的敏感性可通过筛查CYP2B6 * 6来确定。

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