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首页> 外文期刊>Journal of Analytical Toxicology >Sweat testing of MDMA with the Drugwipe analytical device: a controlled study with two volunteers.
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Sweat testing of MDMA with the Drugwipe analytical device: a controlled study with two volunteers.

机译：使用Drugwipe分析设备对MDMA进行汗液测试：由两名志愿者进行的对照研究。

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Rapid on-site tests for the analysis of drugs of abuse in unconventional specimens (e.g., sweat) have recently been developed. Two healthy volunteers familiar with the effects of methylenedioxymethamphetamine (MDMA) were given 100 mg of the drug as a single oral dose. MDMA and its main metabolite 4-hydroxy-3-methoxymethamphetamine (HMMA) were determined in plasma and urine by gas chromatography-mass spectrometry (GC-MS). MDMA was also investigated in sweat with the Drugwipe (an immunochemical strip test). Subjects' armpits were swabbed for 10 s at 0 time (predose) and at 2, 6, 8, 12, and 24 h after MDMA administration. MDMA consumption could be detected using Drugwipe at 2 h and for as long as 12 h after drug administration. However, in one of the volunteers, a faint color change appeared at 0 time, when plasma and urine tested negative for MDMA and did not disappear even 48 h later. Plasma concentrations of MDMA and HMMA measured by GC-MS peaked at 2-4 h, and values greater than 20 ng/mL for MDMA and of 40 ng/mL for HMMA were still detected at 24 h. Urine tested positive by GC-MS for MDMA and HMMA in the 48-h collection period. These findings preliminarily support sweat testing with Drugwipe for monitoring MDMA use.
机译：最近已经开发出快速的现场测试，用于分析非常规标本（例如汗液）中的滥用药物。两名熟悉亚甲二氧基甲基苯丙胺（MDMA）作用的健康志愿者单次口服100毫克该药。通过气相色谱-质谱法（GC-MS）测定血浆和尿液中的MDMA及其主要代谢物4-羟基-3-甲氧基甲基苯丙胺（HMMA）。还使用Drugwipe（免疫化学剥离试验）研究了汗液中的MDMA。在施用MDMA后0时（服药前）和2、6、8、12和24 h擦拭受试者的腋窝10 s。服用药物后2小时和长达12小时，都可以使用Drugwipe检测到MDMA消耗。然而，在其中一名志愿者中，血浆和尿液检测到的MDMA阴性，在0时出现了微弱的颜色变化，甚至在48小时后也没有消失。通过GC-MS测定的MDMA和HMMA的血浆浓度在2-4 h达到峰值，并且在24 h仍检测到MDMA大于20 ng / mL，HMMA大于40 ng / mL。在48小时的收集期内，尿液通过GC-MS检测为MDMA和HMMA阳性。这些发现初步支持使用Drugwipe进行汗液测试以监测MDMA的使用。

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