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首页> 外文期刊>Journal of Analytical Toxicology >Screening method for seventy psychoactive drugs or drug metabolites in serum based on high-performance liquid chromatography--electrospray ionization mass spectrometry.
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Screening method for seventy psychoactive drugs or drug metabolites in serum based on high-performance liquid chromatography--electrospray ionization mass spectrometry.

机译：基于高效液相色谱-电喷雾电离质谱法的血清中七十种精神活性药物或药物代谢物的筛选方法

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摘要

A screening method for 70 psychoactive drugs or drug metabolites in human serum by solid-phase extraction with subsequent high-performance liquid chromatography and electrospray ionization mass spectrometry was developed. Enhanced selectivity of detection was obtained by collision-induced dissociation using two different skimmer voltages for the individual scan. The mass spectra and the retention times of the compounds were incorporated into a self-generated spectra library for identification in screening experiments. The detection limits were found to be between 0.1 and 5 ng/mL serum for the majority of the compounds when measured in the selected ion mode. Because of the very small serum concentrations and the rather low extraction yield, lysergide could not be detected in this way. It was demonstrated with 140 serum samples from alcohol-related traffic cases that this method is suitable for a routine screening in a forensic laboratory.
机译：建立了固相萃取-高效液相色谱-电喷雾电离质谱法分离人血清中70种精神活性药物或药物代谢物的方法。使用两个不同的分离器电压进行个体扫描，通过碰撞诱导的解离获得增强的检测选择性。化合物的质谱和保留时间被合并到一个自生成的谱库中，用于筛选实验中的鉴定。当在选定的离子模式下测量时，大多数化合物的检测限为0.1至5 ng / mL血清。由于血清浓度非常低且提取率相当低，因此无法以这种方式检测到麦角酰麦角麦角。从与酒精有关的交通案件的140个血清样本中证明，该方法适用于法医实验室的常规筛查。

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