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首页> 外文期刊>Journal of Analytical Toxicology >Comparison of urinary excretion characteristics of ethanol and ethyl glucuronide.
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Comparison of urinary excretion characteristics of ethanol and ethyl glucuronide.

机译：乙醇和葡萄糖醛酸乙酯尿排泄特性的比较。

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摘要

This study compared the urinary excretion characteristics of ethyl glucuronide (EtG) with that of ethanol, with focus on the effect of water-induced diuresis. Six healthy volunteers ingested an ethanol dose of 0.5 g/kg (range 25.0-41.5 g) as 5% (v/v) beer in 30 min and the same volume of water after 3 h. Urine collections were made before starting the experiment and at timed intervals over 31.5 h. The concentration of EtG was determined by an LC-MS method (LOQ = 0.1 mg/L). The urine samples collected immediately before starting drinking were all negative for ethanol and EtG, thus confirming that the participants had not recently ingested alcohol. Intake of beer resulted in a marked increase in excreted urine volume and a concomitant drop in creatinine concentration. The concentration of ethanol peaked at a mean value of 17 mmol/L in the 1.5-h urine collection. Except for one subject, EtG was first detectable (range 0.9-5.5 mg/L) at 1 h. Intake of water at 3 h produced another increase in urine volume and a drop in creatinine. The ethanol concentration curve was not influenced by the water diuresis, whereas this caused a distinct drop in the EtG concentration. When EtG was expressed relative to the creatinine value, this ratio was seemingly not affected by the intake of water. The ethanol concentration returned to zero at 6.5 h, whereas EtG was still detectable for up to 22.5-31.5 h, albeit at low levels in the end (< 1 mg/l). Only about 0.02% of the administered dose of ethanol (on a molar basis) was recovered in the urine as EtG. The results demonstrated that EtG remains detectable in the urine for many hours after the ethanol itself has been eliminated. Moreover, it was possible to lower the concentration of EtG by drinking large amounts of water prior to voiding, whereas this strategy did not influence the EtG/creatinine ratio or the concentration of ethanol.
机译：这项研究比较了葡萄糖醛酸乙酯（EtG）和乙醇的尿排泄特性，重点研究了水诱导的利尿作用。六名健康志愿者在30分钟内以0.5（v / v）的啤酒摄入0.5 g / kg（范围25.0-41.5 g）的乙醇剂量，并在3小时后摄入了相同体积的水。在开始实验之前并在超过31.5小时的时间间隔内收集尿液。通过LC-MS方法（LOQ ＝ 0.1mg / L）确定EtG的浓度。即将开始饮酒之前收集的尿液样本中的乙醇和EtG均为阴性，因此证实参与者最近没有摄入酒精。摄入啤酒会导致尿液排泄量显着增加，肌酐浓度随之下降。在1.5小时的尿液收集中，乙醇的浓度峰值为17 mmol / L。除一名受试者外，EtG在1 h时首次被检测到（范围0.9-5.5 mg / L）。 3小时进水会导致尿量增加和肌酐下降。乙醇浓度曲线不受水利尿的影响，但是这导致EtG浓度明显下降。当相对于肌酐值表达EtG时，该比例似乎不受水摄入的影响。乙醇浓度在6.5 h时回到零，而EtG长达22.5-31.5 h仍可检测到，尽管最终浓度很低（<1 mg / l）。尿液中只有约0.02％的乙醇（以摩尔计）被回收为EtG。结果表明，除去乙醇本身后，EtG在尿液中仍可检测许多小时。此外，可以通过在排尿前喝大量的水来降低EtG的浓度，而该策略不会影响EtG /肌酐的比值或乙醇的浓度。

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