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首页> 外文期刊>Journal of Analytical Toxicology >Acetylcodeine as a marker of illicit heroin in human hair: method validation and results of a pilot study.
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Acetylcodeine as a marker of illicit heroin in human hair: method validation and results of a pilot study.

机译：乙酰可待因作为人发中非法海洛因的标志物：方法验证和一项初步研究结果。

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摘要

Acetylcodeine (AC), which is an impurity of illicit heroin synthesis, was suggested as a marker of heroin abuse. A procedure for simultaneous quantitation of 6-monoacetylmorphine (6-MAM), which is the major metabolite of heroin, morphine, codeine, and AC in hair was developed. Fifty-milligram hair samples were incubated in 0.01 M HCl overnight at 60 degrees C. The resulting hydrolyzed solutions were extracted by an automated solid-phase extraction procedure and drugs were analyzed by gas chromatography-mass spectrometry in selected ion monitoring mode (SIM). This required prior derivatization with propionic anhydride. Different validation parameters, such as linearity, intra-assay accuracy, extraction recoveries, and limit of quantitation, were described. Seventy-three hair samples from heroin abusers and 43 hair samples from subjects who had completed a heroin-maintenance program were analyzed. AC was detected in 92% of the first sample group and in only 12% of the second sample group. In the two groups, about 98% of AC-positive samples were found. These results prove that AC can be considered as a suitable marker of illicit heroin use, along with 6-MAM detection.
机译：乙酰可待因（AC）是海洛因非法合成的一种杂质，被认为是海洛因滥用的标志。建立了同时定量头发中海洛因，吗啡，可待因和AC的主要代谢物6-单乙酰吗啡（6-MAM）的程序。将五十毫克的头发样品在0.01 M HCl中于60摄氏度孵育过夜。通过自动固相萃取程序萃取所得的水解溶液，并通过气相色谱-质谱法以选定的离子监测模式（SIM）分析药物。这需要事先用丙酸酐衍生化。描述了不同的验证参数，例如线性，测定内准确性，提取回收率和定量限。分析了来自海洛因滥用者的73个头发样本和来自完成了海洛因维护计划的受试者的43个头发样本。第一个样本组中有92％检出了AC，而第二个样本组中只有12％检出了AC。在两组中，发现约98％的AC阳性样本。这些结果证明，与6-MAM检测一起，AC可以被认为是非法使用海洛因的合适标记。

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