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首页> 外文期刊>Journal of Anatomy >The subiculum: what it does, what it might do, and what neuroanatomy has yet to tell us.
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The subiculum: what it does, what it might do, and what neuroanatomy has yet to tell us.

机译：下腔：它的作用，可能的作用以及尚未告知我们的神经解剖学。

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The subiculum is a pivotal but under-investigated structure positioned between the hippocampus proper and entorhinal and other cortices, as well as a range of subcortical structures. The subiculum has a range of electrophysiological and functional properties which are quite distinct from its input areas; given the widespread set of cortical and subcortical areas with which it interacts, it is able to influence activity in quite disparate brain regions. The rules governing plasticity of synaptic transmission in the hippocampal-subicular axis are poorly understood; this axis appears to share some properties in common with the hippocampus proper, but behaves quite differently in other respects. Equally, its functional properties are not well understood; it plays an important but ill-defined role in spatial navigation, mnemonic processing and control of the response to stress. Here, I review investigations of synaptic plasticity in the hippocampal-subicular pathway, recordings of subicular neurons in the freely moving behaving animal, the effects of behavioural and other stressors on subicular synaptic plasticity, and anatomical data on the dorso-ventral organization of the subiculum in relation to the hypothalamic-pituitary-adrenal (HPA) axis. I argue that there is a dorso-ventral segregation of function within the subiculum: the dorsal component appears principally concerned with the processing of information about space, movement and memory, whereas the ventral component appears to play a major regulatory role in the inhibition of the HPA axis.
机译：亚下丘是位于海马体与内嗅和其他皮质之间以及一系列皮下结构之间的关键但尚未充分研究的结构。该亚科室具有一系列的电生理和功能特性，这些特性与其输入区域完全不同。鉴于它与之相互作用的皮层和皮层下区域分布广泛，它能够影响截然不同的大脑区域的活动。控制海马-次轴突触传递可塑性的规则知之甚少;该轴似乎具有与海马体相同的一些特性，但在其他方面的行为却大不相同。同样，它的功能特性还不是很清楚。它在空间导航，助记符处理和压力响应控制中起着重要但不确定的作用。在这里，我回顾了海马-亚壁途径中突触可塑性的研究，自由运动的动物中亚壁神经元的记录，行为和其他应激因素对亚壁突触可塑性的影响，以及下丘脑背-腹壁组织的解剖学数据关于下丘脑-垂体-肾上腺（HPA）轴。我认为在下丘脑内存在背腹功能分离：背侧成分主要是与空间，运动和记忆有关的信息处理，而腹侧成分似乎在抑制牙合方面起着主要的调节作用。 HPA轴。

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