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首页> 外文期刊>Journal of Anatomy >Changes in adipocytes and dendritic cells in lymph node containing adipose depots during and after many weeks of mild inflammation.
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Changes in adipocytes and dendritic cells in lymph node containing adipose depots during and after many weeks of mild inflammation.

机译：在轻度发炎的几周内和之后，含脂肪的淋巴结中的脂肪细胞和树突状细胞的变化。

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The time course and cellular basis for inflammation-induced hypertrophy of adipose tissue were investigated over 20 weeks in mature male rats. Mild inflammation was induced by subcutaneous injection of 20 microg lipopolysaccharide into one hind-leg three times/week for 4 or 8 weeks, followed by up to 12 weeks 'rest' without intervention. Mean volume and frequency of apoptosis (TUNEL assay) were measured in adipocytes isolated from sites defined by their anatomical relations to lymph nodes, plus numbers of CCL21-stimulated lymph node-derived and adipose tissue-derived dendritic cells. Experimental inflammation increased dendritic cells and adipocyte apoptosis in the locally stimulated popliteal depot and the lymphoid tissue-associated regions of the contralateral popliteal and mesentery and omentum. Responses declined slowly after inflammation ended, but all measurements from the locally stimulated popliteal depot, and the omentum, were still significantly different from controls after 12 weeks rest. The locally stimulated popliteal adipose tissue enlarged by 5% within 4 weeks and remained larger than the control. We conclude that prolonged inflammation induces permanent enlargement, greater adipocyte turnover and increased dendritic cell surveillance in the adjacent adipose tissue and the omentum. The experiment suggests a mechanism for selective hypertrophy of lymphoid tissue-associated adipose tissue in chronic stress and inflammatory disorders, including impaired lymph drainage, Crohn's disease and HIV-associated lipodystrophy, and a link between evolutionary fitness, sexual selection and aesthetically pleasing body symmetry. It would be useful for further study of molecular mechanisms in inflammation-induced local hypertrophy of adipose tissue and development of specific therapies that avoid interference with whole-body lipid metabolism.
机译：在成年雄性大鼠中研究了20周内炎症诱导的脂肪组织肥大的时程和细胞基础。皮下注射20微克脂多糖至一只后腿，每周3次，每次4或8周，引起轻度炎症，随后长达12周的“休息”而无需干预。在从与淋巴结的解剖关系定义的部位分离的脂肪细胞中，加上CCL21刺激的淋巴结来源的和脂肪组织来源的树突状细胞的数量，测量了平均细胞凋亡的频率和频率（TUNEL分析）。实验性炎症增加了对侧pop，肠系膜和大网膜的局部刺激的pop库和淋巴组织相关区域的树突状细胞和脂肪细胞凋亡。炎症结束后，反应缓慢下降，但休息12周后，来自局部刺激的lite骨储库和网膜的所有测量值仍显着不同于对照组。局部刺激的pop脂肪组织在4周内扩大了5％，并且仍然比对照组大。我们得出的结论是，延长的炎症在邻近的脂肪组织和网膜中引起永久性肿大，更大的脂肪细胞更新和增加的树突状细胞监视。该实验提出了一种在慢性应激和炎症性疾病（包括淋巴引流受损，克罗恩病和HIV相关的脂肪营养不良）中选择性增生淋巴组织相关脂肪组织的机制，以及进化适应性，性选择和美观的人体对称性之间的联系。这对于进一步研究炎症引起的脂肪组织局部肥大的分子机制以及避免干扰全身脂质代谢的特异性疗法的发展将是有用的。

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