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首页> 外文期刊>Journal of anesthesia >Postoperative continuous intravenous infusion of fentanyl is associated with the development of orthostatic intolerance and delayed ambulation in patients after gynecologic laparoscopic surgery.
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Postoperative continuous intravenous infusion of fentanyl is associated with the development of orthostatic intolerance and delayed ambulation in patients after gynecologic laparoscopic surgery.

机译：妇科腹腔镜手术后患者术后连续静脉输注芬太尼与体位不耐症的发展和下床活动延迟有关。

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Early ambulation is essential for rapid functional recovery after surgery; however, orthostatic intolerance may delay recovery and cause syncope, leading to potential serious complications such as falls. Opioids may contribute to orthostatic intolerance because of reduced arterial pressure and associated reduction in cerebral blood flow and oxygenation. This study aimed to examine the effect of postoperative continuous infusion of fentanyl on orthostatic intolerance and delayed ambulation in patients after gynecologic laparoscopic surgery.In this retrospective cohort study, data from 195 consecutive patients who underwent gynecologic laparoscopic surgery were analyzed to evaluate the association between postoperative continuous infusion of fentanyl and the incidence of orthostatic intolerance or delayed ambulation. The primary outcome was defined as delayed ambulation, an inability to ambulate on postoperative day 1. The secondary outcome was defined as orthostatic intolerance and symptoms associated with ambulatory challenge, including dizziness, nausea and vomiting, feeling hot, blurred vision, and eventual syncope. Multivariate logistic regression was used to determine the independent predictors of delayed ambulation and orthostatic intolerance.There were 24 cases with documented orthostatic intolerance and 5 with delayed ambulation. After multivariate logistic regression modeling, postoperative continuous infusion of fentanyl was found to be significantly associated with both orthostatic intolerance [adjusted odds ratio (95% confidence interval), 34.78 (11.12-131.72)] and delayed ambulation [adjusted odds ratio (95% confidence interval), 8.37 (1.23-72.15)].Postoperative continuous infusion of fentanyl is associated with increased orthostatic intolerance and delayed ambulation in patients after gynecologic laparoscopic surgery.
机译：早期走动对于手术后的快速功能恢复至关重要。但是，体位不耐受可能会延迟恢复并引起晕厥，从而导致潜在的严重并发症，例如跌倒。阿片类药物可能会导致体位性不耐受，因为动脉压降低以及相关的脑血流量和氧合减少。本研究旨在探讨妇科腹腔镜手术后患者连续输注芬太尼对体位不耐症和延迟下床的影响。这项回顾性队列研究分析了195例接受妇科腹腔镜手术的连续患者的数据，以评估术后的相关性。持续输注芬太尼和体位不耐受或延迟下床活动的发生。主要结局定义为延迟走动，术后第1天无法走动。次要结局定义为体位不耐症和与门诊挑战相关的症状，包括头晕，恶心和呕吐，感到灼热，视力模糊以及最终晕厥。采用多因素logistic回归分析来确定延迟步行和体位不耐受的独立预测因素。有文献记录的体位性不耐受24例，延迟步行的5例。经过多因素logistic回归建模后，发现芬太尼的术后连续输注与体位性耐受性[校正比值比（95％置信区间），34.78（11.12-131.72）]和延迟下床活动[校正比值比（95％信赖度）显着相关间隔），8.37（1.23-72.15）]。妇科腹腔镜手术后患者连续输注芬太尼与体位耐受性增加和下床活动延迟有关。

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