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首页> 外文期刊>Journal of anesthesia >Cellular and molecular mechanisms regulating vascular tone. Part 2: regulatory mechanisms modulating Ca2+ mobilization and/or myofilament Ca2+ sensitivity in vascular smooth muscle cells.
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Cellular and molecular mechanisms regulating vascular tone. Part 2: regulatory mechanisms modulating Ca2+ mobilization and/or myofilament Ca2+ sensitivity in vascular smooth muscle cells.

机译:调节血管张力的细胞和分子机制。第2部分:调节血管平滑肌细胞中Ca2 +动员和/或肌丝Ca2 +敏感性的调节机制。

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摘要

Understanding the physiological mechanisms regulating vascular tone would lead to better circulatory management during general anesthesia. This two-part review provides an overview of current knowledge about the cellular and molecular mechanisms regulating the contractile state of vascular smooth muscle cells (i.e., vascular tone). The first part reviews basic mechanisms controlling the cytosolic Ca2+ concentration in vascular smooth muscle cells, and the Ca2+-dependent regulation of vascular tone. This second part reviews the regulatory mechanisms modulating Ca2+ mobilization and/or myofilament Ca2+ sensitivity in vascular smooth muscle cells-including Rho/Rho kinase, protein kinase C, arachidonic acid, Ca2+/calmodulin-dependent protein kinase II, caldesmon, calponin, mitogen-activated protein kinases, tyrosine kinases, cyclic nucleotides, Cl- channels, and K+ channels.
机译:了解调节血管紧张度的生理机制将导致全身麻醉期间更好的循环管理。分为两部分的综述概述了有关调节血管平滑肌细胞收缩状态(即血管紧张度)的细胞和分子机制的最新知识。第一部分回顾了控制血管平滑肌细胞中胞质Ca2 +浓度的基本机制,以及Ca2 +依赖性的血管紧张度调节。第二部分回顾了调节血管平滑肌细胞中Ca2 +动员和/或肌丝Ca2 +敏感性的调控机制,包括Rho / Rho激酶,蛋白激酶C,花生四烯酸,Ca2 + /钙调蛋白依赖性蛋白激酶II,钙调蛋白,钙蛋白,促分裂原活化蛋白激酶,酪氨酸激酶,环状核苷酸,Cl-通道和K +通道。

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