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首页> 外文期刊>Journal of affective disorders >Differential performance on tasks of affective processing and decision-making in patients with Panic Disorder and Panic Disorder with comorbid Major Depressive Disorder.
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Differential performance on tasks of affective processing and decision-making in patients with Panic Disorder and Panic Disorder with comorbid Major Depressive Disorder.

机译：恐慌症和合并严重抑郁症的恐慌症患者在情感处理和决策任务上的差异表现。

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BACKGROUND: Neuropsychological studies have provided evidence for deficits in psychiatric disorders, such as schizophrenia and mood disorders. However, neuropsychological function in Panic Disorder (PD) or PD with a comorbid diagnosis of Major Depressive Disorder (MDD) has not been comprehensively studied. The present study investigated neuropsychological functioning in patients with PD and PD + MDD by focusing on tasks that assess attention, psychomotor speed, executive function, decision-making, and affective processing. METHODS: Twenty-two unmedicated patients with PD, eleven of whom had a secondary diagnosis of MDD, were compared to twenty-two healthy controls, matched for gender, age, and intelligence on tasks of attention, memory, psychomotor speed, executive function, decision-making, and affective processing from the Cambridge Neuropsychological Test Automated Battery (CANTAB), Cambridge Gamble Task, and Affective Go/No-go Task. RESULTS: Relative to matched healthy controls, patients with PD + MDD displayed an attentional bias toward negatively-valenced verbal stimuli (Affective Go/No-go Task) and longer decision-making latencies (Cambridge Gamble Task). Furthermore, the PD + MDD group committed more errors on a task of memory and visual discrimination compared to their controls. In contrast, no group differences were found for PD patients relative to matched control subjects. LIMITATIONS: The sample size was limited, however, all patients were drug-free at the time of testing. CONCLUSIONS: The PD + MDD patients demonstrated deficits on a task involving visual discrimination and working memory, and an attentional bias towards negatively-valenced stimuli. In addition, patients with comorbid depression provided qualitatively different responses in the areas of affective and decision-making processes.
机译：背景：神经心理学研究已经为精神分裂症和精神障碍等精神疾病的缺陷提供了证据。但是，尚未全面研究恐慌症（PD）或合并有重度抑郁症（MDD）的PD的神经心理学功能。本研究通过关注评估注意力，心理运动速度，执行功能，决策和情感处理的任务，研究了PD和PD + MDD患者的神经心理功能。方法：将22例未接受药物治疗的PD患者（其中11例具有继发性MDD诊断）与22例健康对照进行比较，在性别，年龄和智力方面对22名健康对照进行匹配，这些注意力，记忆力，精神运动速度，执行功能，剑桥神经心理学自动测试电池（CANTAB），剑桥赌博任务和情感去/不去任务来进行决策和情感处理。结果：相对于匹配的健康对照组，PD + MDD患者表现出对偏价的言语刺激（情感去/不去任务）和更长的决策等待时间（剑桥赌博任务）的注意偏见。此外，与对照组相比，PD + MDD组在记忆和视觉辨别任务上犯下了更多错误。相反，相对于匹配的对照受试者，没有发现PD患者的组差异。局限性：样本量有限，但是，所有患者在测试时均无毒品。结论：PD + MDD患者在涉及视觉辨别力和工作记忆的任务上表现出缺陷，并且对负价刺激产生注意偏见。此外，患有合并症的抑郁症患者在情感和决策过程方面的反应在质量上也有所不同。

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