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首页> 外文期刊>Journal of affective disorders >Clinical and neurocognitive predictors of functional outcome in bipolar euthymic patients: a long-term, follow-up study.
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Clinical and neurocognitive predictors of functional outcome in bipolar euthymic patients: a long-term, follow-up study.

机译：双相性正常人的功能预后的临床和神经认知预测指标：一项长期的随访研究。

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OBJECTIVE: To identify clinical and neurocognitive predictors of long-term functional outcome in patients with bipolar disorder METHODS: A total of 32 subjects who met criteria for bipolar I or II disorder were recruited from the Barcelona Bipolar Disorder Program and were assessed clinically and neuropsychologically at baseline. After an average 4-year follow-up, they were interviewed with the Functioning Assessment Short Test (FAST) to assess functional outcome. Multivariate analyses were applied to identify clinical and neurocognitive predictors of functional outcome. RESULTS: The main regression model for predictors of overall psychosocial functioning identified subclinical depressive symptoms (beta=0.516, t=3.51, p=0.002), and free delayed recall in a verbal memory task (beta=-0.314, t=-2.144, p=0.041), accounting for 36% of the variance. Specific predictors of occupational functioning were, again, subthreshold depression (beta=0.435, t=2.8, p=0.009) and a measure of executive function, digits backwards (beta=-0.347, t=-2.23, p=0.034). This model explained around 28% of the variance (corrected R(2)=0.28; F=6.38, gl=2, p=0.004). CONCLUSIONS: Subdepressive symptomatology together with neurocognitive impairments related to verbal memory and executive functions are predictor variables of long-term functional outcome in bipolar disorder.
机译：目的：确定双相情感障碍患者长期功能结局的临床和神经认知指标。方法：从巴塞罗那双相情感障碍计划中招募了符合双相I或II型障碍标准的32名受试者，并在临床和神经心理学上对其进行了评估。基线。在平均四年的随访之后，他们接受了功能评估短期测试（FAST）的访问，以评估功能结局。应用多变量分析来确定功能预后的临床和神经认知预测指标。结果：总体心理社会功能预测指标的主要回归模型确定了亚临床抑郁症状（β= 0.516，t = 3.51，p = 0.002）和口头记忆任务中的自由延迟回忆（β= -0.314，t = -2.144， p = 0.041），占方差的36％。职业功能的具体预测指标再次是阈下抑郁（β= 0.435，t = 2.8，p = 0.009）和执行功能的量度，是数字倒数（β= -0.347，t = -2.23，p = 0.034）。该模型解释了方差的28％（校正后的R（2）= 0.28; F = 6.38，gl = 2，p = 0.004）。结论：抑郁症的症状以及与语言记忆和执行功能相关的神经认知障碍是双相情感障碍长期功能预后的预测变量。

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