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首页> 外文期刊>Journal of Animal Science >Effects of dietary energy source and level and injection of tilmicosin phosphate on immune function in lipopolysaccharide-challenged beef steers.
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Effects of dietary energy source and level and injection of tilmicosin phosphate on immune function in lipopolysaccharide-challenged beef steers.

机译：饮食能量来源和磷酸替米考星水平及注射量对脂多糖激发的牛ste免疫功能的影响。

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Twenty-four Angus x Hereford crossbred steers (247 kg BW; SE = 2.4 kg) were used in a completely random design to evaluate the effect of energy source and level with or without antibiotic administration on measures of immune function. Steers were fed 1 of 3 dietary treatments: a 70% concentrate diet ad libitum (70AL), a 30% concentrate diet ad libitum (30AL), and a 70% concentrate diet offered in an amount calculated to provide NE(g) intake equal to the 30AL treatment (70RES). Half the steers in each dietary treatment received a s.c. injection of tilmicosin phosphate (ANTI; 1 mL/30 kg of BW); the other half received an equal volume of saline s.c. (SAL). Steers were offered the treatment diets for 28 d before and were administered the ANTI or SAL injections 2 d before indwelling catheters were placed in the jugular vein and 2.0 microg/kg of BW of Escherichia coli lipopolysaccharide (LPS) was administered i.v. Blood serum was collected at 30-min intervals from -2 to 6 h and at 8, 12, 24, 48, and 72 h relative to the LPS challenge. Increased energy intake (70AL) increased (P or = 0.04) DMI, ADG, and rectal temperature (RT) after the challenge compared with the 70RES treatment. The 30AL treatment increased the maximum concentrations and area under the response curve of the proinflammatory cytokines (PIC) interferon-gamma, tumor necrosis factor-alpha, and IL-6 (P or = 0.05) compared with the average of the 70AL and 70RES treatments. Decreased energy intake (70RES vs. 70AL) increased IL-6 (P or = 0.003) but did not significantly increase interferon-gamma and tumor necrosis factor-alpha (P or = 0.14) after LPS administration. Tilmicosin administration decreased the time to attain maximal RT (P = 0.01) by 1 h without altering the peak RT (P = 0.85), and tilmicosin interacted with energy intake to increase prechallenge PIC in 70RES vs. 70AL (P or = 0.05). Results indicate that increased PIC response, presumably resulting from a combination of decreased energy intake and from direct effects of roughage, may be a mode of action for the slight decrease in morbidity that often occurs when newly received, stressed calves are fed roughage-based receiving diets. Tilmicosin phosphate might have immunomodulatory capacity beyond its direct effects on pathogenic bacteria, and these effects could interact with dietary energy intake in cattle.
机译：在完全随机的设计中，使用了二十四只安格斯x赫里福德杂交杂交ers牛（247千克体重，SE = 2.4千克）来评估能量源和水平（有无抗生素）对免疫功能的影响。对3牛进行了3种饮食治疗中的1种喂养：随意摄入70％的浓缩饲料（70AL），随意摄入30％的浓缩饲料（70AL）和70％的浓缩饲料，其计算量应使NE（g）摄入量相等接受30AL治疗（70RES）。每种饮食疗法中有一半的ers牛皮获得了s.c.注射磷酸替米考星（ANTI; 1 mL / 30 kg体重）;另一半接受等量的盐水。 （SAL）。牛在治疗前28天要提供饮食，并在将留置导管放入颈静脉之前2天进行ANTI或SAL注射，并静脉内施用2.0 microg / kg体重的大肠杆菌脂多糖（LPS）。相对于LPS攻击，每隔30分钟从-2到6小时以及在8、12、24、48和72小时收集血清。与70RES治疗相比，攻击后增加的能量摄入（70AL）增加（P <或= 0.04）DMI，ADG和直肠温度（RT）。与70AL和70RES的平均值相比，30AL处理增加了促炎细胞因子（PIC）干扰素-γ，肿瘤坏死因子-α和IL-6的反应曲线下的最大浓度和最大面积（P <或= 0.05）。治疗。服用LPS后，能量摄入的减少（70RES对70AL）增加了IL-6（P <或= 0.003），但并未显着增加干扰素-γ和肿瘤坏死因子-α（P或= 0.14）。替米考星给药可在不改变峰值RT（P = 0.85）的情况下将达到最大RT（P = 0.01）的时间减少1 h，并且替米考星与能量摄入相互作用，可增加70RES与70AL的挑战前PIC（P <或= 0.05） 。结果表明，PIC反应的增加，可能是由于能量摄入减少和粗饲料的直接影响共同导致的，可能是发病率略有降低的一种作用方式，这种疾病的发生通常发生在刚接受新的应激小牛饲喂粗饲料的情况下饮食。磷酸替米考星可能具有的免疫调节能力超出了其对致病菌的直接作用，并且这些作用可能与牛的饮食能量摄入相互作用。

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