Isolation and synthesis of a novel immunosuppressive 17alpha-substituted dammarane from the flour of the Palmyrah palm (Borassus flabellifer).

Revesz L; Hiestand P; La Vecchia-L; Naef R; Naegeli HU; Oberer L; Roth HJ

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Isolation and synthesis of a novel immunosuppressive 17alpha-substituted dammarane from the flour of the Palmyrah palm (Borassus flabellifer).

机译：从Palmyrah棕榈（Borassus flabellifer）的面粉中分离和合成新型的免疫抑制性17α-取代的dammarane。

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The novel triterpene 1 with a dammarane skeleton and a hitherto unknown 17alpha-substitution pattern has been isolated from the Palmyrah palm in low yield and prepared by synthesis in larger quantities. 1 was shown to be an extremely potent immunosuppressant in vitro (MLR; IC50 = 10 ng/ml) and in vivo (DTH; ED50 = 0.01 mg/kg p.o.). A glucocorticoid like activity is excluded.

机译：从丹葵棕榈中分离出具有丹玛烷骨架和迄今未知的17α取代模式的新型三萜1，并通过大量合成制备。 1在体外（MLR; IC50 = 10 ng / ml）和体内（DTH; ED50 = 0.01 mg / kg p.o.）被证明是一种非常有效的免疫抑制剂。排除类似糖皮质激素的活性。

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《Bioorganic and Medicinal Chemistry Letters》 |1999年第11期|共6页
作者
Revesz L; Hiestand P; La Vecchia-L; Naef R; Naegeli HU; Oberer L; Roth HJ;
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正文语种 eng
中图分类药学;生物化学;
关键词
Immunosuppressive Agents; Plant Proteins; Triterpenes; 免疫抑制剂; 植物蛋白质类; 三萜类;

机译：Immunosuppressive Agents;Plant Proteins;Triterpenes;免疫抑制剂;植物蛋白质类;三萜类;

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1. Isolation and synthesis of a novel immunosuppressive 17alpha-substituted dammarane from the flour of the Palmyrah palm (Borassus flabellifer). [J] . Revesz L, Hiestand P, La Vecchia-L, Bioorganic and Medicinal Chemistry Letters . 1999,第11期

机译：从Palmyrah棕榈（Borassus flabellifer）的面粉中分离和合成新型的免疫抑制性17α-取代的dammarane。
2. Physico-chemical and functional characteristics of palmyrah (Borassus flabellifer L) tuber flour [J] . Journal of Plantation Crops . 2013,第3期

机译：棕榈叶块茎面粉的理化和功能特性
3. The neurotoxic effect of palmyrah (Borassus flabellifer) flour re-visited. [J] . Vindika Sumudunie K A, Jansz E R, Sharmini Jayasekera, International Journal of Food Sciences and Nutrition . 2004,第8期

机译：再次考察了棕榈叶（Borassus flabellifer）面粉的神经毒性作用。
4. Indigenous technology in utilizations and handlings of palmyra palm (Borassus flabellifer L.) sap and its quality from two regions of East Java [C] . I.A. Saidi, N. Efendi Nommensen International Conference on Technology and Engineering . 2018

机译：帕尔马拉棕榈（Borassus Flabellifer L.）SAP的利用和处理的本土技术及其从东爪哇两地区的质量
5. Veno-occlusive lesions in the liver of rats after prolonged feeding with palmyrah (Borassus flabellifer) flour. [O] . R. G. Panabokke, S. N. Arseculeratne 1976

机译：长期饲喂白头翁（Borassus flabellifer）面粉后大鼠肝脏的静脉闭塞性病变。
6. MUTAGENICITY OF FLOUR FROM THE PALMYRAH PALM BORASSUS-FLABELLIFER) IN SALMONELLA-TYPHIMURIUM AND ESCHERICHIA-COLI [O] . Andersen Pia Haubro, Poulsen Emil 1985

机译：沙门氏菌（salmyrah palm BassassUs-FLaBELLIFER）面粉在沙门氏菌和大肠杆菌中的致突变性

Isolation and synthesis of a novel immunosuppressive 17alpha-substituted dammarane from the flour of the Palmyrah palm (Borassus flabellifer).

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