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首页> 外文期刊>Journal of anti-aging medicine >Telomerase, telomerase inhibition, and cancer.
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Telomerase, telomerase inhibition, and cancer.

机译：端粒酶，端粒酶抑制和癌症。

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摘要

Telomeres, located at the ends of eukaryotic chromosomes, are synthesized by the enzyme telomerase and are responsible for maintaining chromosome length. The absence of telomerase in most somatic cells has been associated with telomere shortening and aging of these cells. In contrast, high levels of telomerase activity are observed in over 90% of human cancer cells. The absence of telomerase in normal and aging cells is considered a natural defense against development of cancer. However, we do not know what triggers the reappearance of telomerase in cancer cells. Telomerase activity is directly correlated with the expression of its active catalytic component, the human telomerase reverse transcriptase (hTERT), which is believed to be controlled primarily at the level of transcription. Elucidation of the control of telomerase in aging and in cancer as an age-related disease has considerable potential in leading to novel approaches in anti-aging medicine.
机译：端粒位于真核染色体末端，由端粒酶合成，负责维持染色体长度。大多数体细胞中端粒酶的缺乏与这些细胞的端粒缩短和衰老有关。相反，在超过90％的人类癌细胞中观察到高水平的端粒酶活性。正常细胞和衰老细胞中不存在端粒酶被认为是抵抗癌症发展的天然防御手段。但是，我们不知道是什么触发了端粒酶在癌细胞中的重新出现。端粒酶的活性与其活性催化成分，即人类端粒酶逆转录酶（hTERT）的表达直接相关，据信其主要在转录水平受到控制。阐明在衰老和作为与年龄有关的疾病的癌症中端粒酶的控制在产生抗衰老药物的新方法方面具有巨大潜力。

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