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首页> 外文期刊>Journal of anti-aging medicine >The role of somatic and germline mutations in aging and a mutation interaction model of aging.
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The role of somatic and germline mutations in aging and a mutation interaction model of aging.

机译：体细胞和种系突变在衰老中的作用以及衰老的突变相互作用模型。

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Mutations with a deleterious effect that is expressed after the average reproductive period are not effectively selected against and can accumulate in the germline. A conservative estimate is that at least 1-2% of new deleterious mutations affect some aspect of DNA replication, repair, or chromosome segregation. Since deleterious mutations can have an effect even as heterozygotes, this mutation accumulation can create an inherited background of late-acting mutations that themselves enhance mutation rate. This can have an interactive effect, in that it may increase the rate of somatic mutation during an individual's lifetime. The aging individual therefore becomes increasingly mosaic for somatic mutations, which in turn could potentially contribute to the gradual deterioration of biological processes and influence what we experience as senescence. Interventions that reduce somatic and germ cell mutations should, therefore, reduce the aging process in present and future generations.
机译：在平均繁殖期后表达的具有有害作用的突变不能有效地针对种系进行积累，并且会累积在种系中。保守的估计是至少有1-2％的新有害突变会影响DNA复制，修复或染色体分离的某些方面。由于有害突变甚至可以像杂合子一样发挥作用，因此这种突变积累会产生后发突变的遗传背景，从而自身提高了突变率。这可以产生交互作用，因为它可以提高个体一生中的体细胞突变率。因此，衰老的个体越来越成为体细胞突变的镶嵌体，而体细胞突变又有可能导致生物过程的逐渐恶化，并影响我们经历的衰老。因此，减少体细胞和生殖细胞突变的干预措施应减少今世后代的衰老过程。

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