...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of anti-aging medicine >Early programming of adult longevity: demographic and experimental studies.
【24h】

Early programming of adult longevity: demographic and experimental studies.

机译：成人长寿的早期编程：人口统计学和实验研究。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

It is supposed that longevity might be programmed by early life exposures. We had carried out demographic and experimental researches for the examination of the possibility of longevity programming. In demographic study, the recorded deaths in Kiev (Ukraine) between 1990 and 2000 (51,503 men and 50,131 women) were used. Age at death was strongly associated with month of birth. Subjects born in the middle of year (April-July) had the lowest longevity. Increasing longevity was observed with each successive birth-month in the second half of the year, with a peak longevity for births in December. To research of the mechanisms responsible for longevity programming, study of adult D. melanogaster DNA repair capacity after irradiation at the egg stage was carried out, using marker such as DNA strand breaks. Insects irradiated in low doses (0.50 and 0.75 Gy) had extended life span and increased stability to S1 nuclease treatment. The probable explanation of observed postponed effects might be the long-term modulation of certain (possibly repair) genes activity. We hypothesize that life-extending effects of different anti-aging treatments might be a consequence of their unspecific (hormetic) action, rather then specific (geroprotector) action on the some aging-related processes, and induction an "transcriptional reprogramming" may be a key mechanism of the longevity programming and artificial life extension.
机译：据推测，寿命可以通过早期的生活暴露来编程。我们进行了人口统计学和实验研究，以检验长寿计划的可能性。在人口统计研究中，使用了1990年至2000年在基辅（乌克兰）记录的死亡人数（男性51,503人，女性50,131人）。死亡年龄与出生月份密切相关。在年中（4月至7月）出生的受试者的寿命最低。在该年下半年的每个连续出生月份，人们的寿命都在增加，在12月，生育寿命达到了峰值。为了研究负责长寿编程的机制，使用标记物（例如DNA链断裂）对卵期照射后的成年D. melanogaster DNA修复能力进行了研究。低剂量（0.50和0.75 Gy）照射的昆虫具有更长的寿命，并且对S1核酸酶处理的稳定性更高。观察到的延迟效应的可能解释可能是某些（可能是修复的）基因活性的长期调节。我们假设不同的抗衰老疗法延长生命的影响可能是由于它们对某些衰老相关过程的非特异性（激素）作用而不是特异性（geroprotector）作用所致，并且诱导“转录重编程”可能是长寿编程和人工寿命延长的关键机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号