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首页> 外文期刊>Journal of Agricultural and Food Chemistry >CHARACTERIZATION OF MALATHION RESIDUES IN DAIRY GOATS AND POULTRY
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CHARACTERIZATION OF MALATHION RESIDUES IN DAIRY GOATS AND POULTRY

机译：乳山羊和家禽中马拉硫磷残留的表征

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The chemical nature and magnitude of [C-14]malathion residues in the milk, eggs (whites and yolks), fat, liver, kidney, and muscle tissues in dairy goats and laying hens were examined after repeated oral exposure. The level and duration of the dose given to goats were equivalent to 86 ppm on feed for 5 days. Chickens received the equivalent of 28 ppm on feed for 4 days. Radioactive residues were characterized and identified using solvent extraction and chromatography. The parent chemical was not detectable, and immediate metabolites of malathion were not present in any tissues except traces of the mono- and dicarboxylic acid metabolites observed in goat kidney. This observation was consistent with urinary excretion as the major elimination pathway of malathion and immediate metabolites in poultry, laboratory animals, and humans. Extensive degradation and metabolism resulted in the reincorporation of the radiolabel into normal biogenic chemicals in all investigated samples. The products were typical of those derived from the tricarboxylic acid cycle. The products included pyruvate, lactate, lactose, oleic acid, stearic acid, and glycerol. Reincorporation of radiolabel into protein was also demonstrated by the isolation and hydrolysis of casein from milk. It was concluded that ingested malathion was converted to acetate or other volatile fatty acids, metabolized to acetyl-CoA, and then incorporated into the carbon pool.
机译：反复口服后，检查牛奶，鸡蛋（白人和蛋黄），脂肪，肝脏，肾脏和肌肉组织中的[C-14]马拉硫磷残留物的化学性质和大小。给予山羊的剂量水平和持续时间相当于5天的饲料中86 ppm。鸡在4天内的饲料摄入量相当于28 ppm。使用溶剂萃取和色谱法对放射性残留物进行表征和鉴定。母体化学物质不可检测，马拉松的立即代谢产物在任何组织中均不存在，除了在山羊肾脏中观察到痕量的单羧酸和二羧酸代谢产物。该观察结果与尿排泄是家禽，实验动物和人类中马拉硫磷和立即代谢产物的主要消除途径一致。广泛的降解和代谢导致所有研究样品中的放射性标记重新掺入正常的生物化学药品中。该产物是衍生自三羧酸循环的产物的典型产物。产品包括丙酮酸，乳酸，乳糖，油酸，硬脂酸和甘油。从牛奶中酪蛋白的分离和水解也证明了放射性标记重新掺入蛋白质。结论是，摄入的马拉硫磷已转化为乙酸盐或其他挥发性脂肪酸，代谢为乙酰辅酶A，然后并入碳库中。

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