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首页> 外文期刊>Circulation journal >Treatment With Statin on Atheroma Regression Evaluatedby Intravascular Ultrasound With Virtual Histology (TRUTH Study)Rationale and Design
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Treatment With Statin on Atheroma Regression Evaluatedby Intravascular Ultrasound With Virtual Histology (TRUTH Study)Rationale and Design

机译：用虚拟组织学评估血管内超声对他汀类药物治疗对动脉瘤消退的作用（TRUTH研究）理论与设计

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Background Many clinical trials have shown that 3-hydroxy-3-methylglutaryl-conenzyme A reductase inhibitors (statins) can significantly reduce the incidence of coronary artery disease in both primary and secondary prevention. A recent study showed that aggressive lipid-lowering therapy with statins could achieve regression of coronary artery plaque evaluated with gray-scale intravascular ultrasound (IVUS). However, the actual changes in coronary artery plaque composition produced by statin therapy have not been well delineated. Methods and Results This study will be a prospective, open-label, randomized multicenter study of 160 patients with stable or unstable angina who have undergone percutaneous coronary intervention with Virtual Histology? IVUS (VH-IVUS). Patients will be randomly assigned to either the pitavastatin or pravastatin group. After treatment for 24-40 weeks, VH-IVUS will be performed again in the same segment of the coronary artery. The primary endpoint will be quantitative changes in each of the 4 components measured by VH-IVUS.
机译：背景许多临床试验表明，在一级预防和二级预防中，3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂（他汀类药物）可显着降低冠状动脉疾病的发生率。最近的一项研究表明，使用他汀类药物进行积极的降脂治疗可以通过灰度血管内超声（IVUS）评估实现冠状动脉斑块的消退。然而，他汀类药物疗法产生的冠状动脉斑块成分的实际变化尚未得到很好的描述。方法和结果该研究将是一项对160例经过虚拟组织学经皮冠状动脉介入治疗的稳定型或不稳定型心绞痛患者进行的前瞻性，开放标签，随机多中心研究。 IVUS（VH-IVUS）。将患者随机分为匹伐他汀或普伐他汀组。在治疗24至40周后，将在冠状动脉的同一部分再次进行VH-IVUS。主要终点将是通过VH-IVUS测量的4种组分中每种组分的定量变化。

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