...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Agricultural and Food Chemistry >ROLE OF CYTOCHROME P450 ISOFORMS IN THE METABOLISM OF ABAMECTIN AND IVERMECTIN IN RATS
【24h】

ROLE OF CYTOCHROME P450 ISOFORMS IN THE METABOLISM OF ABAMECTIN AND IVERMECTIN IN RATS

机译：细胞色素P450亚型在大鼠阿米汀和伊维菌素代谢中的作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abamectin (AVM) and ivermectin (IVM) are each metabolized by rat liver microsomes to 3 ''-O-desmethyl(3 ''-ODMe), 24-hydroxymethyl (24-OHMe), and 26-hydroxymethyl (26-OHMe) derivatives. Microsomes from rats pretreated with dexamethasone(Dex), but not 3-methylcholanthrene (3MC), increased the formation of 3 ''-ODMe metabolites of both AVM and IVM. Troleandomycin inhibited formation of 3 ''-ODMe metabolites by >80% by microsomes from Dex-induced rats. Therefore, cytochrome P450 3A plays a major role in this metabolic pathway. Formation of the 26-OHMe metabolites was markedly increased by microsomes from SMC-treated but not Dex-treated rats. Formation of 24-OHMe from AVM, but not IVM, was slightly increased by microsomes from 3MC-treated rats. Consistent with this observation, anti-rat cytochrome P450 1Al inhibited formation of 26-OHMe metabolites of AVM and IVM by 90 and 40%, respectively. This antibody also inhibited formation of the 24-OHMe metabolite from AVM by 60% but not from IVM. Thus, cytochrome P450 1A1 is involved in the hydroxylation of the 26-methyl group of both AVM and IVM as well as the 24-methyl group of AVM but not the 24-methyl group of IVM.
机译：大鼠肝脏微粒体将阿维菌素（AVM）和伊维菌素（IVM）分别代谢为3''-O-去甲基（3''-ODMe），24-羟甲基（24-OHMe）和26-羟甲基（26-OHMe）衍生品。用地塞米松（Dex）预处理但未用3-甲基胆甾烯（3MC）预处理的大鼠微粒体增加了AVM和IVM的3''-ODMe代谢产物的形成。 Troleandomycin抑制了来自Dex诱导的大鼠的微粒体的3''-ODMe代谢物形成> 80％。因此，细胞色素P450 3A在此代谢途径中起主要作用。 26-OHMe代谢产物的形成显着增加了由SMC处理但未进行Dex处理的大鼠的微粒体。由3MC处理的大鼠的微粒体会稍微增加AVM而非24-VM形成的24-OHMe。与该观察结果一致，抗大鼠细胞色素P450 1A1分别抑制了AVM和IVM的26-OHMe代谢物的形成90％和40％。该抗体还抑制了AVM中24-OHMe代谢物的形成，但抑制了IVM中24-OHMe代谢物的形成。因此，细胞色素P450 1A1参与了AVM和IVM的26-甲基以及AVM的24-甲基而不是IVM的24-甲基的羟基化。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号