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首页> 外文期刊>Journal of Agricultural and Food Chemistry >HPLC DETERMINATION OF SULFADIAZINE RESIDUES IN COHO SALMON (ONCORHYNCHUS KISUTCH) WITH CONFIRMATION BY LIQUID CHROMATOGRAPHY WITH ATMOSPHERIC PRESSURE CHEMICAL IONIZATION MASS SPECTROMETRY
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HPLC DETERMINATION OF SULFADIAZINE RESIDUES IN COHO SALMON (ONCORHYNCHUS KISUTCH) WITH CONFIRMATION BY LIQUID CHROMATOGRAPHY WITH ATMOSPHERIC PRESSURE CHEMICAL IONIZATION MASS SPECTROMETRY

机译：液相色谱-常压化学电离质谱法测定HPLC法测定银鲑鱼中的磺胺嘧啶残留

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摘要

High-performance liquid chromatography and postcolumn derivatization with fluorescamine were used to determine sulfadiazine (SDZ) residues in muscle and skin from salmon dosed with Tribrissen. Determinations in the fish ranged from 0.2 to 21600 ng of SDZ/g; in each fish tested, the concentration of SDZ in the skin was at least twice that in the muscle. Liquid chromatography with atmospheric pressure chemical ionization mass spectrometry (LC-APCI/MS) was used to confirm SDZ residues. In-source collision induced dissociation was optimized to produce a mass spectrum containing the protonated molecule and four fragment ions. Sulfadiazine was confirmed in muscle fortified with 10 ng of SDZ/g and in muscle from fish dosed with SDZ by the accurate agreement of ion intensity ratios generated from muscle compared with those generated from SDZ standard injections.
机译：高效液相色谱法和用荧光胺进行柱后衍生用于测定鲑鱼中Tribrissen剂量后肌肉和皮肤中磺胺嘧啶（SDZ）的残留量。鱼中的测定范围为0.2至21600 ng SDZ / g;在测试的每条鱼中，皮肤中SDZ的浓度至少是肌肉中SDZ的两倍。使用常压化学电离质谱（LC-APCI / MS）进行液相色谱法确认SDZ残留物。优化了源内碰撞诱导的解离，以产生包含质子化分子和四个碎片离子的质谱。确认磺胺嘧啶在强化了10 ng SDZ / g的肌肉中以及用SDZ给药的鱼的肌肉中，通过肌肉产生的离子强度比与从SDZ标准注射产生的离子强度比的精确一致，证实了磺胺嘧啶。

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