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首页> 外文期刊>Journal of Agricultural and Food Chemistry >INSECTICIDAL PROPERTIES OF SOME DERIVATIVES OF L-CANAVANINE
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INSECTICIDAL PROPERTIES OF SOME DERIVATIVES OF L-CANAVANINE

机译：L-Canavanine的某些衍生物的杀虫特性

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摘要

The canavanine derivatives D-canavanine and L-homocanavanine as well as the 1-methyl and 1-ethyl esters of L-canavanine were synthesized and evaluated for biological activity in fifth instar larvae of the tobacco hornworm, Manduca sexta [Sphingidae]. While L-homocanavanine did not increase intrinsic toxicity, it was as deleterious as L-canavanine. D-Canavanine was biologically active, as demonstrated by its ability to cause larval edema, but the D-enantiomer had little ability to elicit the larval growth inhibition and pupal deformity which are hallmarks of canavanine toxicosis and was postulated to be linked to aberrant protein production. The 1-methyl and 1-ethyl esters of L-canavanine were synthesized to determine if enhancing canavanine's hydrophobicity might increase its bioavailability. Our experiments revealed that these esters are less toxic than canavanine; the ethyl ester disrupted larval growth more than did the methyl analogue.
机译：合成了Canavanine衍生物D-canavanine和L-homocanavanine，以及L-canavanine的1-甲基酯和1-乙基酯，并评价了烟草天蛾幼虫（Manduca sexta）[Sphingidae]在五龄幼虫中的生物活性。尽管L-高卡那碱不增加内在毒性，但它与L-高卡那碱一样有害。 D-Canavanine具有生物活性，可引起幼虫水肿，但D-对映异构体几乎没有引起幼虫生长抑制和p畸形的能力，这些都是Canavanine中毒的标志，并被认为与异常蛋白的产生有关。 。合成了L-canavanine的1-甲基和1-乙基酯，以确定增强的canavanine的疏水性是否会增加其生物利用度。我们的实验表明，这些酯的毒性低于卡那万胺。与甲基类似物相比，乙酯对幼虫生长的破坏更大。

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